Hydrogen-rich Water for Molecular and Phenotypic Biomarkers of Aging

Not Applicable

Completed

• Conditions: Aging
• Interventions: Dietary Supplement: Hydrogen-rich water; Other: Control Water

• Registration Number: NCT04430803
• Lead Sponsor: University of Novi Sad, Faculty of Sport and Physical Education

Brief Summary

This study evaluates the effects of six-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in men and women aged 70 years and over.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-06-07
• Study First Submitted QC: 2020-06-11
• Study First Posted: 2020-06-12
• Study Start: 2020-09-15
• Primary Completion: 2021-03-15
• Status Verified: 2021-04
• Study Completion: 2021-04-01
• Last Update Submitted: 2021-04-26
• Last Update Posted: 2021-04-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• Age > 70 years
• Free of acute disorders

Exclusion Criteria

• History of dietary supplement use during the past 4 weeks

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Hydrogen-rich water	Hydrogen-rich water	Hydrogen-rich water (Rejuvenation, HRW Natural Health Products Inc.) * 8 ppm of hydrogen * Administered one dose two times per day on an empty stomach in the morning and at the evening
Control water	Control Water	Tap water * 0 ppm of hydrogen * Administered one dose two times per day on an empty stomach in the morning and at the evening

Primary Outcome Measures

Name	Time	Method
Change in TeloTAGGG Telomerase PCR activity in serum	Baseline vs. 6 months post-intervention	Baseline vs. 6 months

Secondary Outcome Measures

Name	Time	Method
Change in DNA methylation	Baseline vs. 6 months post-intervention	Baseline vs. 6 months
Change in blood concentration of advanced glycation end product	Baseline vs. 6 months post-intervention	Baseline vs. 6 months
Change in lipid peroxidation	Baseline vs. 6 months post-intervention	Baseline vs. 6 months
Change in ADAS-Cog score (0-70 scale, higher scores indicating greater cognitive impairment)	Baseline vs. 6 months post-intervention	Baseline vs. 6 months
Change in serum FGF21	Baseline vs. 6 months post-intervention	Baseline vs. 6 months
Change in facial wrinkling (0-100 scale; higher scores mean worse outcome)	Baseline vs. 6 months post-intervention	Baseline vs. 6 months
Change in serum TET2	Baseline vs. 6 months post-intervention	Baseline vs. 6 months
Change in maximal oxygen uptake estimated by step-in-place test	Baseline vs. 6 months post-intervention	Baseline vs. 6 months

Trial Locations

Locations (1)

FSPE Applied Bioenergetics Lab; 🇷🇸 Novi Sad, Vojvodina, Serbia