Hydrogen-rich Water for Molecular and Phenotypic Biomarkers of Aging
Not Applicable
Completed
- Conditions
- Aging
- Registration Number
- NCT04430803
- Lead Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
- Brief Summary
This study evaluates the effects of six-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in men and women aged 70 years and over.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
- Age > 70 years
- Free of acute disorders
Exclusion Criteria
- History of dietary supplement use during the past 4 weeks
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change in TeloTAGGG Telomerase PCR activity in serum Baseline vs. 6 months post-intervention Baseline vs. 6 months
- Secondary Outcome Measures
Name Time Method Change in DNA methylation Baseline vs. 6 months post-intervention Baseline vs. 6 months
Change in blood concentration of advanced glycation end product Baseline vs. 6 months post-intervention Baseline vs. 6 months
Change in lipid peroxidation Baseline vs. 6 months post-intervention Baseline vs. 6 months
Change in ADAS-Cog score (0-70 scale, higher scores indicating greater cognitive impairment) Baseline vs. 6 months post-intervention Baseline vs. 6 months
Change in serum FGF21 Baseline vs. 6 months post-intervention Baseline vs. 6 months
Change in facial wrinkling (0-100 scale; higher scores mean worse outcome) Baseline vs. 6 months post-intervention Baseline vs. 6 months
Change in serum TET2 Baseline vs. 6 months post-intervention Baseline vs. 6 months
Change in maximal oxygen uptake estimated by step-in-place test Baseline vs. 6 months post-intervention Baseline vs. 6 months
Trial Locations
- Locations (1)
FSPE Applied Bioenergetics Lab
🇷🇸Novi Sad, Vojvodina, Serbia
FSPE Applied Bioenergetics Lab🇷🇸Novi Sad, Vojvodina, Serbia