NCT04430803已完成不适用
The Effects of Six-month Hydrogen-rich Water Intake on Molecular and Phenotypic Biomarkers of Aging in Men and Women Aged 70 Years and Over: a Randomized-controlled Trial
University of Novi Sad, Faculty of Sport and Physical Education2 个研究点 分布在 1 个国家目标入组 44 人开始时间: 2020年9月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Change in TeloTAGGG Telomerase PCR activity in serum
研究概览
简要总结
This study evaluates the effects of six-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in men and women aged 70 years and over.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age > 70 years
- •Free of acute disorders
排除标准
- •History of dietary supplement use during the past 4 weeks
结局指标
主要结局
Change in TeloTAGGG Telomerase PCR activity in serum
时间窗: Baseline vs. 6 months post-intervention
Baseline vs. 6 months
次要结局
- Change in DNA methylation(Baseline vs. 6 months post-intervention)
- Change in blood concentration of advanced glycation end product(Baseline vs. 6 months post-intervention)
- Change in lipid peroxidation(Baseline vs. 6 months post-intervention)
- Change in ADAS-Cog score (0-70 scale, higher scores indicating greater cognitive impairment)(Baseline vs. 6 months post-intervention)
- Change in serum FGF21(Baseline vs. 6 months post-intervention)
- Change in facial wrinkling (0-100 scale; higher scores mean worse outcome)(Baseline vs. 6 months post-intervention)
- Change in serum TET2(Baseline vs. 6 months post-intervention)
- Change in maximal oxygen uptake estimated by step-in-place test(Baseline vs. 6 months post-intervention)
研究者
研究点 (2)
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