Phase II Study of Corifollitropin Alfa Followed by hpHMG in a Long GnRH Agonist Protocol for the Treatment of Poor Ovarian Responders
Overview
- Phase
- Phase 2
- Intervention
- Triptorelin
- Conditions
- Infertility
- Sponsor
- Universitair Ziekenhuis Brussel
- Enrollment
- 57
- Locations
- 1
- Primary Endpoint
- Ongoing pregnancy rate
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The purpose of the present study is to examine the level of ovarian response and the pregnancy rates among poor ovarian responders treated with a novel treatment protocol with 150μg corifollitropin alfa followed by 300IU hMG in a long GnRH agonist protocol.
Detailed Description
Corifollitropin alfa reaches maximum concentrations (Cmax), between 25 and 45 h after injection , a time interval which is significantly shorter as compared to treatment with rFSH. The investigators hypothesized that this rapid increase in the serum FSH concentration may result in a significantly higher exposure of the small antral follicles to constant high levels of FSH during the early follicular phase, securing not only the recruitment of the follicles, but also the continued growth. In the current study the investigators examine whether administration of corifollitropin followed by 300IU hMG in a long GnRH agonist protocol may result in acceptable pregnancy rates in poor ovarian responders fulfilling the "Bologna criteria"
Investigators
Nikolaos P. Polyzos
Principal Investigator
Universitair Ziekenhuis Brussel
Eligibility Criteria
Inclusion Criteria
- •Patients should fulfill the "Bologna criteria" for poor ovarian response
- •At least two of the following three features must be present:
- •i. Advanced maternal age (≥40 years) or any other risk factor for POR (poor ovarian response); ii. A previous POR (≤3 oocytes with a conventional stimulation protocol); iii. An abnormal ovarian reserve test (i.e. AFC \<7 follicles or AMH \<1.1 ng/ml).
- •Two episodes of POR after maximal stimulation are sufficient to define a patient as poor responder in the absence of advanced maternal age or abnormal ORT (ovarian reserve test).
Exclusion Criteria
- Not provided
Arms & Interventions
Corifollitropin Alfa + hMG
Intervention: Triptorelin
Corifollitropin Alfa + hMG
Intervention: Corifollitropin alfa 150μg
Corifollitropin Alfa + hMG
Intervention: hpHMG
Outcomes
Primary Outcomes
Ongoing pregnancy rate
Time Frame: 10 to 12 weeks of gestation
Secondary Outcomes
- Number of oocytes retrieved(Day of oocyte retrieval)
- Cycles with oocyte retrieval(Day of oocyte retrieval)
- Cycles with embryo transfer(Day of Embryo transfer)