Docetaxel in Treating Children With Recurrent Solid Tumors
- Conditions
- Brain and Central Nervous System TumorsNeuroblastomaSarcoma
- Interventions
- Biological: filgrastim
- Registration Number
- NCT00002825
- Lead Sponsor
- National Cancer Institute (NCI)
- Brief Summary
Phase II trial to study the effectiveness of docetaxel in treating children with recurrent solid tumors. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Detailed Description
OBJECTIVES:
I. Determine the response rate to docetaxel in children with recurrent sarcomas, neuroblastomas, or brain tumors.
II. Describe the toxic effects of docetaxel in these patients.
OUTLINE:
All patients receive docetaxel with G-CSF every 21 days for up to 12 courses. Patients are followed for survival.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Arm I filgrastim All patients receive docetaxel with G-CSF every 21 days for up to 12 courses. Arm I docetaxel All patients receive docetaxel with G-CSF every 21 days for up to 12 courses.
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (36)
Children's Hospital of Orange County
🇺🇸Orange, California, United States
Indiana University Cancer Center
🇺🇸Indianapolis, Indiana, United States
Children's National Medical Center
🇺🇸Washington, District of Columbia, United States
UCSF Cancer Center and Cancer Research Institute
🇺🇸San Francisco, California, United States
University of Minnesota Cancer Center
🇺🇸Minneapolis, Minnesota, United States
Mayo Clinic Cancer Center
🇺🇸Rochester, Minnesota, United States
University of Michigan Comprehensive Cancer Center
🇺🇸Ann Arbor, Michigan, United States
Princess Margaret Hospital for Children
🇦🇺Perth, Western Australia, Australia
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Long Beach Memorial Medical Center
🇺🇸Long Beach, California, United States
Children's Hospital Los Angeles
🇺🇸Los Angeles, California, United States
NYU School of Medicine's Kaplan Comprehensive Cancer Center
🇺🇸New York, New York, United States
Memorial Sloan-Kettering Cancer Center
🇺🇸New York, New York, United States
Herbert Irving Comprehensive Cancer Center
🇺🇸New York, New York, United States
Lineberger Comprehensive Cancer Center, UNC
🇺🇸Chapel Hill, North Carolina, United States
Huntsman Cancer Institute
🇺🇸Salt Lake City, Utah, United States
Children's Mercy Hospital
🇺🇸Kansas City, Missouri, United States
Kaiser Permanente Medical Center-Sacramento
🇺🇸Sacramento, California, United States
Jonsson Comprehensive Cancer Center, UCLA
🇺🇸Los Angeles, California, United States
Doernbecher Children's Hospital
🇺🇸Portland, Oregon, United States
Children's Hospital of Denver
🇺🇸Denver, Colorado, United States
Holden Comprehensive Cancer Center at The University of Iowa
🇺🇸Iowa City, Iowa, United States
St. Joseph's Hospital and Medical Center
🇺🇸Paterson, New Jersey, United States
University of Chicago Cancer Research Center
🇺🇸Chicago, Illinois, United States
Children's Hospital of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Children's Hospital of Pittsburgh
🇺🇸Pittsburgh, Pennsylvania, United States
Children's Hospital Medical Center - Cincinnati
🇺🇸Cincinnati, Ohio, United States
IWK Health Centre
🇨🇦Halifax, Nova Scotia, Canada
Ireland Cancer Center
🇺🇸Cleveland, Ohio, United States
Children's Hospital of Columbus
🇺🇸Columbus, Ohio, United States
University of Texas - MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
Vanderbilt-Ingram Cancer Center
🇺🇸Nashville, Tennessee, United States
University of Wisconsin Comprehensive Cancer Center
🇺🇸Madison, Wisconsin, United States
Children's Hospital and Regional Medical Center - Seattle
🇺🇸Seattle, Washington, United States
Fred Hutchinson Cancer Research Center
🇺🇸Seattle, Washington, United States
British Columbia Children's Hospital
🇨🇦Vancouver, British Columbia, Canada