Sarcopenia in patients suffering from rheumatoid arthritis and osteoarthritis, a pilot study.

• Conditions: muscle weakness; sarcopenia; 10027665; 10028393

• Registration Number: NL-OMON31760
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

rheumatoid arthritis
osteoarthritis
age 45-70 years

Exclusion Criteria

no

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. On a cellular level: differences in satellite cell number, proliferative<br /><br>potential of myoblasts, differential capacity of myoblasts, cellular capacity<br /><br>to react to the exposure to oxidative stress, presence of muscle atrophy.<br /><br>2. On a systemic level: differences in the systemic inflammatory status, number<br /><br>of lymphocyte subsets.<br /><br>3. On a functional level: differences in handgrip strength, leg press strength,<br /><br>isometric knee extensor strength.<br /><br>4. On an imaging level: differences in muscle architecture. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>No secondary outcome.</p><br>