Establishment of a Tumor Bank for Tissue Samples

Recruiting

• Conditions: Lung Neoplasms; Ovarian Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Neoplasms of the Female Genitalia; Endocrine Gland Neoplasms
• Interventions: Other: Tumor tissue collection; Other: Sampling of ascites and pleural effusion; Other: Collecting urine samples; Other: Collecting saliva sample; Other: Collecting sputum; Other: Collecting stool samples; Other: Lavage/Irrigation

• Registration Number: NCT01789229
• Lead Sponsor: Medical University of Vienna

Brief Summary

Establishment of a tumor bank, consisting of tissue samples of tumor patients (benign and malign tumors) and healthy people as controls. The tissue samples will be collected systematically together with the corresponding clinical data. The biological samples, the clinical date together with prospective experimental date constitute the entity of the tissue tumor bank.

This tumor bank for tissue samples, together with our tumorbank for blood samples (NCT01763125) combined constitute the entity "Tumorbank".

Detailed Description

Recent progress in diagnosis and therapy of cancer diseases can be ascribed mainly to translational research. The relevance of "translational oncology" will only increase in the future -"From bench to bedside" - the swift implementation of new science research results in clinical studies in order to expedite progress in clinical cancer therapy for the benefit of the patient.

Its almost a matter of course in the medical science today to collect biological samples together with clinical information thereby creating the foundation for future excellent fundamental research.

The aim of this tumor bank is to consist of biological samples (together with a blood bank - see NCT01763125) and isolates of tumor patients and healthy people as controls. The biological samples, the clinical date together with prospective experimental date constitute the entity of the tumor bank. The content of the tumor bank can provide essential material for current and future research (e.g. analyses of prognostic or predictive tumor markers; genetically analysis (polymorphism, mutation, hypermethylation; verification and characterisation of disseminated tumor cells).

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2003-09
• Study First Submitted: 2013-02-07
• Study First Submitted QC: 2013-02-07
• Study First Posted: 2013-02-12
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-21
• Last Update Posted: 2023-03-23
• Primary Completion: 2026-12
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 10000

Inclusion Criteria

• Male/Female
• Age 18 to 90 years max.
• Just one current known malignant disease or just one current inflammatory disease

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Exclusion Criteria

• Inflammatory disease and malignant disease
• multiple malignancies
• multiple diseases
• underage

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Malignant tumors	Collecting saliva sample	Patients who have one of the Neoplasms stated above under "conditions".
Benign controls	Collecting saliva sample	Patients with a benign tumor or an inflammatory disease - to be matched by age.
Malignant tumors	Collecting urine samples	Patients who have one of the Neoplasms stated above under "conditions".
Benign controls	Collecting stool samples	Patients with a benign tumor or an inflammatory disease - to be matched by age.
Healthy controls	Collecting saliva sample	People/patients who have no known disease at time of sampling or are admitted to the hospital for minor interventions and have no inflammatory disease.
Malignant tumors	Collecting sputum	Patients who have one of the Neoplasms stated above under "conditions".
Benign controls	Collecting urine samples	Patients with a benign tumor or an inflammatory disease - to be matched by age.
Healthy controls	Collecting stool samples	People/patients who have no known disease at time of sampling or are admitted to the hospital for minor interventions and have no inflammatory disease.
Malignant tumors	Tumor tissue collection	Patients who have one of the Neoplasms stated above under "conditions".
Benign controls	Tumor tissue collection	Patients with a benign tumor or an inflammatory disease - to be matched by age.
Healthy controls	Collecting urine samples	People/patients who have no known disease at time of sampling or are admitted to the hospital for minor interventions and have no inflammatory disease.
Malignant tumors	Sampling of ascites and pleural effusion	Patients who have one of the Neoplasms stated above under "conditions".
Malignant tumors	Collecting stool samples	Patients who have one of the Neoplasms stated above under "conditions".
Malignant tumors	Lavage/Irrigation	Patients who have one of the Neoplasms stated above under "conditions".
Healthy controls	Collecting sputum	People/patients who have no known disease at time of sampling or are admitted to the hospital for minor interventions and have no inflammatory disease.
Benign controls	Sampling of ascites and pleural effusion	Patients with a benign tumor or an inflammatory disease - to be matched by age.
Benign controls	Collecting sputum	Patients with a benign tumor or an inflammatory disease - to be matched by age.
Benign controls	Lavage/Irrigation	Patients with a benign tumor or an inflammatory disease - to be matched by age.
Healthy controls	Lavage/Irrigation	People/patients who have no known disease at time of sampling or are admitted to the hospital for minor interventions and have no inflammatory disease.

Primary Outcome Measures

Name	Time	Method
Establishment of blood/tissue bank consisting of oncological samples from cancer patients and benign and healthy controls.	14 years

Trial Locations

Locations (3)

Medical University Vienna, Dptm. of Obstetrics & Gynaecology; 🇦🇹 Vienna, Austria

Charité University - Campus Virchow Chlinic; 🇩🇪 Berlin, Germany

University Hospitals Leuven - Department of Obstetrics and Gynaecology; 🇧🇪 Leuven, Belgium