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An International, Stepped-Wedge, Cluster-Randomized Trial Investigating the 0/1-hour Algorithm in Suspected Acute Coronary Syndrome in Asia:The rational of the DROP-Asian ACS study

Not Applicable
Conditions
acute coronary syndrome
Registration Number
JPRN-UMIN000042461
Lead Sponsor
Juntendo University Nerima Hospital Department of Cardiovascular and biology
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Complete: follow-up continuing
Sex
All
Target Recruitment
3728
Inclusion Criteria

Not provided

Exclusion Criteria

ST elevation myocardial infarction On chronic hemodialysis A clear alternative case for the symptoms othe than ACS Symptomatic patients with atrioventricular nodal re-entrant tachycardia demonstrate ST-segment depressions and relevant troponin kinetics. Because it is impossible to make a different diagnosis with type 1 MI, type 2 MI, MI with non-obstructive coronary arteries, or acute myocardial injury, we decided not to include these patients. Acute heart failure due to already known non-coronary heart disease without suspected ACS. Congestive heart failure with hypoxemia Infection Cariogenic shock Dementia (Mini Mental State Examination; MMSE less than 20). Confirmed primary pulmonary disease without suspected ACS. Traumatic chest pain with preceded thorax injury without suspected ACS. Inability or unwillingness to provide informed consent

Study & Design

Study Type
Interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Primary outcome measure is the incidence of major adverse cardiac events (MACE), defined as the composite of cardiovascular death, new acute myocardial infarction (AMI) (type 1 or 2), unstable angina, or unexpected revascularization within 30 days (defined as any unplanned hospitalization with cardiac revascularization performed within the first 12 h after hospital admission in the context of ACS).
Secondary Outcome Measures
NameTimeMethod
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