Role of Pulse Co-oximetry in Prehospital Emergency Medical Service Management of Suspected Carbon Monoxide Poisoning : A Prospective Multicenter Study.
试验速览
- 阶段
- 不适用
- 入组人数
- 176
- 试验地点
- 1
- 主要终点
- SpCO optimal threshold value for detection of CO poisoning
研究概览
简要总结
The RAD-57 pulse CO-oximeter is a lightweight device allowing non-invasive measurement of blood carboxyhemoglobin. Previous studies comparing RAD-57 measurements (SpCO) to standard laboratory blood gas analysis (COHb) have reported contradictory results.
the RAD-57 pulse CO-oximeter could be useful as a first-line screening test for acute CO poisoning, enabling rapid detection and management of patients with suspected CO poisoning in the prehospital emergency setting This study assesses the diagnostic value of pulse CO-oximetry, comparing SpCO to standard laboratory blood measurement for prehospital management of patients with suspected carbon monoxide (CO) poisoning.
详细描述
Transcutaneous SpCO will be obtained using the RAD-57 simultaneously with blood sampling for laboratory blood gas analysis, at the time of prehospital management by emergency medical services. The diagnostic performance of SpCO for the screening of CO poisoning will be determined using ROC curve analysis, and Blood COHb levels >5% and 10% as the reference standard for CO poisonning for non-smokers and smokers respectively. Correlation between SpCO and COHb will be assessed using Bland and Altman's method.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient aged 18 years or older
- •Patient managed by prehospital emergency medical services.
- •Patient with a suspected CO exposure presenting or not with clinical signs of CO poisoning
排除标准
- •Patient for whom venous blood sampling cannot be obtained prehospitally
- •Patient for whom SpCo measurement cannot be performed prehospitally (cardiac arrest, peripheral vasoconstriction)
研究组 & 干预措施
SpCO and COHb measurement
SpCO measurement (Experimental) : Non invasive pulse CO-oximetry will be carried out in all patients simultaneously with venous blood sampling for standard laboratory blood gas analysis, at time of prehospital management by emergency medical services
COHb measurement (Active comparator) : Blood carboxyhemoglobin testing will be carried out in all patients
干预措施: RAD57 measurement (SpCO) (Device)
SpCO and COHb measurement
SpCO measurement (Experimental) : Non invasive pulse CO-oximetry will be carried out in all patients simultaneously with venous blood sampling for standard laboratory blood gas analysis, at time of prehospital management by emergency medical services
COHb measurement (Active comparator) : Blood carboxyhemoglobin testing will be carried out in all patients
干预措施: CO-oximeter (Device)
结局指标
主要结局
SpCO optimal threshold value for detection of CO poisoning
时间窗: Baseline
prehospital medical management
次要结局
- COHb Blood carboxyhemoglobin level(Baseline)
- SpCO level(Baseline)