Aerobic Interval Training in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Hypoxemia

Not Applicable

Completed

• Conditions: Hypertension, Pulmonary; Pulmonary Disease, Chronic Obstructive; Hypoxia
• Interventions: Other: Exercise

• Registration Number: NCT03092622
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

Patients with severe Chronic Obstructive Pulmonary Disease (COPD) and low oxygen levels in the blood are at risk of developing pulmonary hypertension and strain on the right side of the heart, both of which are known to increase symptoms and worsen prognosis It is not fully established whether interval exercise training in patients with severe COPD and concomitant low oxygen levels is beneficial.

This study aims to evaluate the effects of aerobic interval exercise training in patients with severe COPD and low oxygen levels in the blood, with a particular emphasis on such effects on the cardiovascular system and pulmonary circulation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-02-22
• Study First Submitted QC: 2017-03-27
• Study First Posted: 2017-03-28
• Study Start: 2017-04-01
• Primary Completion: 2019-12-31
• Study Completion: 2019-12-31
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-29
• Last Update Posted: 2020-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Chronic Obstructive Pulmonary Disease (COPD)
• Forced Expiratory Volume 1 second (FEV1) <60% of predicted
• FEV1%FVC <70 % of predicted (FVC = Forced Vital Capacity)
• Qualify for Long term oxygen therapy (LTOT), or presence of significant desaturation on exercise.

Exclusion Criteria

• Unstable ischaemic heart disease or valvular heart disease.
• Active malignant disease.
• Substance abuse.
• Physical or mental disability that prevents participation in the exercise programme or testing.
• Pregnancy.
• Exacerbation of COPD or respiratory tract infection last 6 weeks before.
• Completed pulmonary rehabilitation programme or other organised exercise programme last 3 month
• Use of high doses of systemic steroids.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
exercise training	Exercise	Outpatients treadmill interval training, 4x4 minutes with 3 minutes in between at lower intensity. 3 sessions weekly for 10 weeks to a total of 30 sessions.

Primary Outcome Measures

Name	Time	Method
Pulmonary artery pressure	Change from baseline at 10 weeks	Examined by right heart catheterisation

Trial Locations

Locations (1)

St Olavs Hospital, Lungemedisinsk Avdeling & Hjertemedisinsk Avdeling; 🇳🇴 Trondheim, Norway