Healthy Aging: Effects of Time-specific Exercise on Functional, Structural, Metabolic and Immune Parameters in Circadian Context
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Osteopenia
- Sponsor
- Comenius University
- Enrollment
- 34
- Locations
- 1
- Primary Endpoint
- Bone mineral density
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
The project aims to explore the mechanisms, by which physical activity can support healthy ageing and decrease the negative impact of ageing on the circadian system, musculoskeletal system and immunity.
Detailed Description
The main aim of the project is to examine the effect of as well as of the three-month, timely specific training intervention on the functionality of circadian organization in elderly volunteers. The additive aim is to examine the effect of lifelong endurance physical activity, along with the experimental training intervention on the body composition, bone density, and selected hormonal, biochemical, histological and molecular indicators of metabolic health. Partial aims are as follows:n to explore the effect of morning and afternoon training on the most significant parameters, identified by the previous cross-sectional study, in sedentary elderly. Furthermore, to clarify adaptation mechanisms of experimental training protocol on selected parameters, that may explain possible differences in mechanisms of active and passive aging.
Investigators
Eligibility Criteria
Inclusion Criteria
- •no history of regular physical activity training and exercise of more than 150 minutes of moderate or 75 minutes of higher intensity per week.
- •Body mass index (BMI) between 18.5 and 30 kg/m2 for all groups
- •Exclusion criteria for probands will be:
- •Recent or current infection, physical disability,
- •malignant, cardiovascular, metabolic, autoimmune diseases,
- •Malnutrition and pharmacological interference (e.g., steroids, non-steroidal anti-inflammatory agents, immunosuppressive and antineoplastic drugs).
- •Use of performance enhancing drugs in the past and during the study period will condition exclusion.
Exclusion Criteria
- •recent or current infection, physical disabilities,
- •malignant, cardiovascular, metabolic, autoimmune diseases,
- •Malnutrition and pharmacological interference (e.g., steroids, nonsteroidal anti-inflammatory agents, immunosuppressive and antineoplastic drugs).
- •Use of performance-enhancing drugs in the past and during the study period will condition exclusion.
Outcomes
Primary Outcomes
Bone mineral density
Time Frame: 12 weeks
The proportion of total body fat mass, visceral fat mass, total body mass and bone density will be measured using Dual-energy X-ray Absorptiometry (DXA, hologic fan-beam bone densitometer Discovery QDR series). The DXA testing procedure will follow Kralik et al. (2019). All DXA procedures will be performed by a board-certified radiologist.