Evaluation of Finastride Effect in Different Dosage on the Amount of Perioperative Bleeding in Transurthral Resection of Prostate

Phase 2

Completed

• Conditions: Benign Prostate Hyperplasia
• Interventions: Procedure: TURP

• Registration Number: NCT01627522
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

Preoperative use of finastride will decrease the amount of perioperative blood loss during and after TURP

The effect of finastride on decreasing the amount of perioperative blood loss during and after TURP is dose dependent

Finastride will decrease microvascular density in prostate tissue and this effect is dose dependent

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2012-06-21
• Study First Submitted QC: 2012-06-22
• Study First Posted: 2012-06-25
• Primary Completion: 2013-03
• Study Completion: 2013-05
• Status Verified: 2016-04
• Last Update Submitted: 2016-04-19
• Last Update Posted: 2016-04-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• Patients with BPH that require TURP

Exclusion Criteria

• Previous prostate surgery
• Prostate Cancer
• Coagulopathy
• The use of NSAIDs, Anticoagulants, Antiplatelet drugs
• CRF/ESRD

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Finastide high dose	TURP	4 weeks of daily 5mg finastride before operation
Finastide low dose	TURP	2 weeks of daily 5mg finastride before operation

Primary Outcome Measures

Name	Time	Method
Perioperative Hb Drop	24 hours after surgery

Trial Locations

Locations (1)

Faghihi Hospital; 🇮🇷 Shiraz, Fars, Iran, Islamic Republic of