The interrelationships between changes in the metabolic state and homeostasis of the bone and injection of a new substance during orthodontic tooth movement

Not Applicable

Conditions: Skeletal class II and moderate maxillary protrusion
Musculoskeletal Diseases

Registration Number: ISRCTN99776766

Lead Sponsor: Damascus University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Ongoing

Sex: All

Target Recruitment: 40

Inclusion Criteria

1. Patient who has a second class II as light to medium with 42. In the vertical plane, a natural or slight vertical growth pattern
3. Moderate anchorage, where the molar and canine relationships are cusp to cusp
4. The mandibular dental arch is well aligned or slightly crowed and does not require extraction treatment
5. A patient with good oral health and healthy periodontal tissue
6. A patient who does not take any medications
7. A patient who has not undergone previous orthodontic treatment

Exclusion Criteria

1. Patients who have a severe structural defect in the sagittal plane
2. Patients who have a severe horizontal or vertical growth pattern
3. The patient who has moderate to severe crowding in the lower dental arch requires extraction to treat it
4. Patients with general diseases or craniofacial syndromes
5. Pregnant or breastfeeding

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. The amount of slippage of the upper first molars mesially during retraction<br>2. The inclination of the axes of the upper first molars<br>3. Rotation of maxillary first molars<br>4. The height of the alveolar bone in the injection area<br>5. The thickness of the alveolar bone in the injection area<br>6. Root resorption of maxillary first molars<br>Measured using cone beam computed tomography (CBCT) before the start of orthodontic treatment and after the end of the mass retraction

Secondary Outcome Measures