Comparison of Scores for Early Brain Damage Assessment at Intensive Care Unit Admission After Cardiac Arrest

Recruiting

• Conditions: Cardiac Arrest

• Registration Number: NCT05606809
• Lead Sponsor: AfterROSC

Brief Summary

Even in patients with successful return of spontaneous circulation (ROSC), outcome after cardiac arrest remains poor. The overall in-hospital survival rate widely varies both worldwide and across communities, from 1 to 4 folds according to circumstances of arrest and post-resuscitation interventions. Several studies have already shown that early interventions performed after ROSC, such as treatment of the cause, targeted temperature management, optimal hemodynamic management and extra-corporeal life support in selected patients, could improve the outcome in post-cardiac arrest patients. However, the decision process regarding the allocation of these resources, in parallel with the management of patients' proxies, remains a complex challenge for physicians facing these situations. Consequently, several prediction models and scores have been developed in order to stratify the risk of unfavorable outcome and to discriminate the best candidates for post-resuscitation interventions. Overall, several scores exist, but external validation are lacking and direct comparisons are needed to assess relative interest of scoring systems. Indeed, establishing the optimal scoring system is crucial, for optimal treatment allocation and appropriate information to relatives.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-10-31
• Study Start: 2022-11-02
• Study First Submitted QC: 2022-11-04
• Study First Posted: 2022-11-07
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-29
• Last Update Posted: 2024-01-30
• Primary Completion: 2025-12-02
• Study Completion: 2025-12-02

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 4500

Inclusion Criteria

• all adult patients, major, admitted to intensive care after cardiac arrest (after both in and out-of hospital cardiac arrest),
• comatose (defined by Glasgow score ≤ 8) on admission,

Exclusion Criteria

• cardiac arrest occurring intra-hospital,
• minor patient,
• major patient under guardianship,
• protected persons,
• prior inclusion in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determination of Area Under Curve of Cerebral Admission Hospital Prognosis (CAHP) Score at intensive care unit admission	Intensive Care Unit Admission (Usually 3 hours after cardiac arrest	Determination of AUC for CAHP score as compare to Utstein style criteria.; CAHP score range from 0 to 300 with higher score indicates poorer prognosis

Trial Locations

Locations (5)

APHP, Cochin; 🇫🇷 Paris, France

Hopital Jacques Cartier; 🇫🇷 Massy, France

CHU Nantes; 🇫🇷 Nantes, Pays De Loire, France

Clinique Ambroise Paré; 🇫🇷 Neuilly-sur-Seine, France

CH Versailles; 🇫🇷 Versailles, France