ACTRN12610000390088
Not yet recruiting
Phase 2
Pilot study for the rapid alleviation of depression in depressed alcohol dependent persons using ketamine
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversity of Otago
- Enrollment
- 24
- Status
- Not yet recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diagnostic Statistical Manual \- fourth edition, text revision (DSM\-IV\-TR) alcohol dependence; major depression with Montgomery\-Asberg Depression Rating Scale (MADRS) scores \>20 able and willing to give informed consent.
Exclusion Criteria
- •Current chaotic multiple substance use (excluding alcohol, and tobacco — see medication below); currently in active moderate to severe alcohol withdrawal; actively suicidal or homicidal; pregnancy, nursing or refusal to use a reliable method of birth control in female subjects; severe psychiatric symptoms for which hospitalisation is being seriously considered; evidence of significant cerebral, renal, thyroid or cardiac disease; severe liver disease or liver failure.
- •Medication: Disallowed medication: lamotrigine, memantine, amantadine, riluzole, N\-acetylcysteine within 2 weeks; Monamine Oxidase Inhibitors (MAOIs) within 4 weeks; escalating doses of opioids.
Outcomes
Primary Outcomes
Not specified
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