Effect-site Concentration of Remifentanil for Double-lumen Tubes Intubation: Airtraq VS Macintosh Laryngoscope

Not Applicable

Completed

• Conditions: Hemodynamic Instability; Intubation Complication
• Interventions: Device: Airtraq; Device: Macintosh

• Registration Number: NCT03653910
• Lead Sponsor: Huazhong University of Science and Technology

Brief Summary

The 50% effective concentration of remifentanil by target controlled infusion was not determined for inhibiting the haemodynamic response during double-lumen tube (DLT) intubation. Previous study showed that Airtraq videolaryngoscope provided more stable haemodynamics than Macintosh for double-lumen tube intubation. In this study, the investigators will compare the 50% effective concentration of remifentanil between Airtraq videolaryngoscope and Macintosh laryngoscope for inhibiting haemodynamic responses during DLT intubation.

Detailed Description

Dixon "up-and-down" method was used to determine 50% effective concentration of remifentanil by target controlled infusion for inhibiting the haemodynamic responses during DLT intubation with Airtraq videolaryngoscope or Macintosh laryngoscope.

Study Timeline

• Study First Submitted: 2018-08-06
• Study First Submitted QC: 2018-08-29
• Study First Posted: 2018-08-31
• Study Start: 2018-09-03
• Status Verified: 2019-05
• Primary Completion: 2019-05-10
• Study Completion: 2019-05-17
• Last Update Submitted: 2019-05-18
• Last Update Posted: 2019-05-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Airtraq	Airtraq	Patients received DLT intubation by Airtraq videolarygoscope
Macintosh	Macintosh	Patients received DLT intubation by Macintosh laryngoscope

Primary Outcome Measures

Name	Time	Method
Remifentanil TCI effect site concentration	through study completion, an average of 20 min	preestablish remifentanil TCI effect site concentration(ng/ml)

Secondary Outcome Measures

Name	Time	Method
Narcotrend index	at entering the operation room(T1), at immediately before DLT intubation(T2), at immediately after DLT intubtion(T3), at 1 minute(T4)/2 minutes (T5)/3 minutes(T6) after DLT intubation	Narcotrend index in Arabic numerals
mean arterial pressure	at entering the operation room(T1), at immediately before DLT intubation(T2), at immediately after DLT intubtion(T3), at 1 minute(T4)/2 minutes (T5)/3 minutes(T6) after DLT intubation	mean arterial pressure in mmHg
heart rate	at entering the operation room(T1), at immediately before DLT intubation(T2), at immediately after DLT intubtion(T3), at 1 minute(T4)/2 minutes (T5)/3 minutes(T6) after DLT intubation	heart rate in bpm

Trial Locations

Locations (1)

Tongji Hospital, Huazhong University of Science and Technology; 🇨🇳 Wuhan, Hubei, China