Evaluation of Biomarkers for the Assessment of Disease Activity of Eosinophilic Esophagitis (EoE) in Childre

Phase 4

Conditions: K20
K21
T78.1
Oesophagitis
Gastro-oesophageal reflux disease
Other adverse food reactions, not elsewhere classified

Registration Number: DRKS00014688

Lead Sponsor: Abteilung für Gastroenterologie und HepatologieKinderklinik Erlangen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 100

Inclusion Criteria

Pediatric patients including 18 years of age with clinical or laboratorial suspicion of eosinophilic esophagitis

Exclusion Criteria

- Other causes for esophageal eosinophilia like chronic inflammatory bowel disease or celiac diesase
- Esophageal candidosis or infection with Herpes simplex
- Present esophageal gastritis or esophageal Enteritis
- Ongoing Treatment with immunosuppressive or immunomodulating substances

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- Identification ot the most effective treatment branch as assessed by histological criteria for disease remission<br>- Identification of biomarkers and their applicability in childhood to reduce the frequency of gastroscopies for follow up

Secondary Outcome Measures

Name	Time	Method
- Identification of tolerance mechanisms to predict the optimal time for reintroduction ot the eliminated food allergen<br>- Applicability of allergological skin tests (sensitivity, specificity, positive and negative predictive value) in childhood EoE (Eosinophilic Esophagitis)<br>- Evaluation whether a susccessful tratment of EoE has an iompact on improving pulmonary obstruction (bronchial asthma) in affected children