Evaluation Of The Efficacy Of The Modified Atkins Diet In Children With Refractory Epilepsy: A Randomized Controlled Trial.

AIIMS0 个研究点目标入组 96 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•1)Age: 2 ? 14 years.
•2) Seizures persisting daily or more than 7 per week despite the appropriate use of at least 3 anti-epileptic drugs.

•1)Known or suspected inborn error of metabolism:
•Clinical suspicion of metabolic disorder as evidenced by 2 or more of the following- a history of parental consanguinity, prior affected siblings, unexplained vomiting, intermittent worsening of symptoms, recurrent episodes of lethargy, altered sensorium, or ataxia, hepatosplenomegaly on examination
•With or without 2 or more of the following biochemical abnormalities
•High blood ammonia (>80mmol/L), High arterial lactate (>2 mmol/L), metabolic acidosis (pH <7.2), hypoglycaemia (blood sugar <40 mg/dl), abnormal urinary aminoacidogram, presence of reducing sugars or ketones in urine, and positive results on urine neurometabolic screening tests.
•2)Motivational or psychosocial issues in the family which would preclude compliance
•3)Systemic illness- chronic hepatic, renal or pulmonary disease

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