Incidence of glaucoma conversion in patients with large cup to disc ratio

• Conditions: patients with large cup to disc ratio (more than or equal to 0.5); glaucoma suspected; glaucoma conversion; large cup to disc ratio; enlarge cupping

• Registration Number: TCTR20220928004
• Lead Sponsor: Faculty of Medicine Siriraj Hospital, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-09-28
• Study Completion: 2022-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 340

Inclusion Criteria

1. Patients with a cup to disc ratio more than or equal to 0.5 (reported from OCT result) from Faculty of Medicine, SIriraj hospital during 2008 - 2021
2. Intraocular pressure does not exceed 21 mmHg by regular inspection (at least 3 times per year)
3. No glaucomatous visual field defect reported by Humphrey visual field
4. Patients have at least 1 fundus photography
5. Patients have at least 1 optical coherence tomography

Exclusion Criteria

1. Patients who have other ophthalmologic conditions that affect optic disc, cornea, retina, visual field, and intraocular pressure (except cataract)
2. Patients who receive intraocular surgeries or interventions which affect intraocular pressure before enrolling in this study
3. Patients who can not cooperate with Humphrey visual field test
4. Patients who do not have adequate information from the medical record (requires at least three years consecutively)

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glaucoma conversion rate any time after enrolling the patients incidence rate

Secondary Outcome Measures

Name	Time	Method
Risk factors for developing glaucoma any time after enrolling the patients Kaplan-Meier Graph with Hazard ratio