Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression

Phase 4

• Conditions: Major Depression

• Registration Number: NCT00291239
• Lead Sponsor: Zentrum für Integrative Psychiatrie

Brief Summary

40 patients with the diagnosis of major depression are included. There are two interventions: partial sleep deprivation (PSD) and normal night sleep (CTRL). Patients are randomly assigned to PSD-(2 undisturbed nights)-CTRL or CTRL-(2 undisturbed nights)-PSD. Cytokine-status, neuropsychological and psychopathometric status are assessed pre and post each interventional and control condition.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-02
• Study First Submitted: 2006-02-09
• Study First Submitted QC: 2006-02-10
• Study First Posted: 2006-02-13
• Primary Completion: 2008-12
• Status Verified: 2009-04
• Last Update Submitted: 2009-04-02
• Last Update Posted: 2009-04-03
• Study Completion: 2009-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Major depression
• Informed consent

Exclusion Criteria

• Known epilepsy or previous unexplained loss of consciousness after sleep deprivation
• Bipolar disorder
• Acute or chronic inflammatory diseases
• Psychosis
• Suicidal tendency
• Pregnancy or nursing

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
cognition
cytokine concentration

Secondary Outcome Measures

Name	Time	Method
clinical improvement

Trial Locations

Locations (1)

Zentrum für Integrative Psychiatrie; 🇩🇪 Kiel, Germany