Effects of Delivery Mode of Cognition Intervention in Early Alzheimer's Disease
Phase 2
Completed
- Conditions
- Alzheimer's Disease
- Interventions
- Behavioral: Cognitive Training
- Registration Number
- NCT00611312
- Lead Sponsor
- University of Kansas
- Brief Summary
The purpose of this study is to see if an intense two-week long cognitive training program helps the thinking ability of adults with very mild Alzheimer Disease. We anticipate that scores on clinical cognitive tests will be better after the training.
- Detailed Description
Twenty of the 30 subjects will be recruited to participate in functional magnetic resonance imaging (fMRI). Scanning will be done while subjects perform a verbal learning task. Ten subjects will be scanned before and after the two week training. Another ten will be scanned twice at a two week interval before beginning the cognitive training.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
- Diagnosis of very mild Alzheimer's Disease (CDC of 0.5) and mild Alzheimer's Disease (CDC of 1.0)
Exclusion Criteria
- Neurologic disorder other than Alzheimer's disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 1 Cognitive Training Cognitive Training
- Primary Outcome Measures
Name Time Method Composite score of 5 cognitive tests including 1)WAIS digit span, 2) word fluency, 3) trail making test-A 4) Rey Osterrieth complex figure and 5) MMSE 2 weeks with FU at 2 and 4 months
- Secondary Outcome Measures
Name Time Method Brain activity during functional brain imaging 2 weeks
Trial Locations
- Locations (1)
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States