Evaluation of the chronological changes of plasma levobupivacaine concentration after performing M-TAPA.
Not Applicable
- Conditions
- The patients undergoing abdominal surgery longer than 2 hours under general anesthesia in conjunction with M-TAPA.
- Registration Number
- JPRN-UMIN000045406
- Lead Sponsor
- Hokkaido university hospital, department of anesthesiology
- Brief Summary
25 mL of 0.25% levobupivacaine mixed with epinephrine was administered on each side. The highest individual peak and mean peak plasma concentration was 1.03 and 073, respectively.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Not provided
Exclusion Criteria
1. ASA-PS >=3 2. Allergy to local anesthetics or epinephrine 3. Body weight <=50 kg 4. Existing hepatopathy or neuropathy 5. Pregnancy 6. Albumine <=3 g/dL 7. Other patients who are judged inappropriate by the investigator
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The plasma levobupivacaine concentration at 10, 20, 30, 45, 60, 120 minutes after performing M-TAPA.
- Secondary Outcome Measures
Name Time Method 1. Correlation with plasma local anesthetic concentration and patient's characteristics. 2. Adverse events occurring within 12 hours after M-TAPA performance.