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INTermittent ERythromycin versus Infusion: Comparative study in the critically ill (INTERIC study).

Not yet recruiting
Conditions
Feeding intolerability in the critically ill patients.
Diet and Nutrition - Other diet and nutrition disorders
Registration Number
ACTRN12615001271594
Lead Sponsor
Flinders Medical Centre
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Not yet recruiting
Sex
All
Target Recruitment
40
Inclusion Criteria

All of these: (i) Age > 18 years; (ii) availability of informed consent from patient or next of kin (iii)decision by treating clinical to initiate erythromycin for feed intolerance and (iv) patient on metoclopramide.

Exclusion Criteria

(i) Pregnancy, (ii) Allergy for macrolide antibiotics or metoclopramide, (iii) QTc greater or equal to 500 msec, (iv) suspected mechanical bowel obstruction or perforation, (v) administration of more than one dose of erythromycin within the previous 24 hrs, (vi) administration of drugs known to interact with erythromycin (carbamazepine, cyclosporine, theophylline, aminophylline, digoxin, oral anticoagulants), (vii) myasthenia gravis (viii) evidence of liver dysfunction (i.e., more than three times elevation above the upper end of normal range of bilirubin, glutamyl transferase, aspartate transaminase, alanine transaminase, or lactate dehydrogenase), (ix) severe renal failure (GFR 15 – 29 ml/min/1.73m2) without renal replacement therapy.

Study & Design

Study Type
Interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Secondary Outcome Measures
NameTimeMethod

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