Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Knee Osteoarthritis
Not Applicable
Completed
- Conditions
- Knee Osteoarthritis
- Registration Number
- NCT05398874
- Lead Sponsor
- Kufa University
- Brief Summary
To assess the efficacy and safety of the Ginkgo biloba extract in patients with Knee OA.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- patients 40-75 years old with knee OA.
- Grade II and Grade III according to the Kellgrenn-Lawrence (KL) grading system of radiographic OA.
Exclusion Criteria
- Pregnancy, breastfeeding
- Liver or renal problems
- Patient taking any drug that might interact with Ginkgo extract (eg. warfarin, etc.)
- patient with cardiovascular or cerebral vascular disorders, uncontrolled diabetes, allergic to ginkgo, recent surgery or hospital admission, >75 years old.
- Allergic or contraindicated to using NSAIDs
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method KOOS score Changes occured : baseline , 2 weeks , 4 weeks ,and 8 weeks 42 item questionnaire to assess pain, other symptoms, activities of daily living (ADL), sport and recreation function (Sport/Rec) and knee-related quality of life (QOL).
- Secondary Outcome Measures
Name Time Method IL-6 Changes occured: baseline , 4 weeks,and 8 weeks Serum level of interleukin 6
TNF-alpha Changes occured: baseline , 4 weeks,and 8 weeks Serum level of tumour necrosis factor - alpha
urinary CTX-II Changes occured :baseline , 4 weeks,and 8 weeks C-terminal telopeptide of type II collagen from urine samples
Trial Locations
- Locations (1)
Private Clinic
🇮🇶Najaf, N/A (Outside Of US), Iraq
Private Clinic🇮🇶Najaf, N/A (Outside Of US), Iraq