Proteomic and Physiological Markers of Exercise-induced Physiological Stress and Fatigue in Grand Tour Cycling
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 7
- 试验地点
- 1
- 主要终点
- Serum proteome abundance of cyclists during Tour de France
研究概览
简要总结
This project aims to identify the effect of a 3-week grand tour (e.g. Tour de France) on physiological markers and the blood proteome in world-class cyclists.
详细描述
Blood samples will be collected in world-tour cyclists in the fasted state (i) before, (ii) on the first resting day, (ii) on the second resting day, and (iv) on the final day of the Tour de France. Samples collected before and on the final day will be analyzed by proteomics, while sample from all timepoints will be assessed for specific cytokines to identify physiological markers of fatigue. In addition, questionnaires will be used to evaluate subjective feelings of fatigue and appetite.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Cyclist participating in the Tour de France
排除标准
- •Younger than 18years old
结局指标
主要结局
Serum proteome abundance of cyclists during Tour de France
时间窗: Start of the Tour de France (day 0) - last day of the Tour de France (day 23)
Change in serum proteome between start and end of Tour de France
Serum GDF15 (Growth and differentiation factor 15) concentration
时间窗: Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23)
Serum GDF15 throughout the grand tour
Blood haemoglobin concentration
时间窗: Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23)
Haematological profile of cyclists
次要结局
- White blood cell concentration(Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23))
- Serum Leptin concentration(Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23))
- Serum free BDNF (brain-derived neutrophic factor) concentration(Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23))
- Red blood cell concentration(Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23))
- Serum ghrelin concentration(Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23))
- Serum FGF21 (fibroblast growth factor 21) concentration(Start of the Tour de France (day 0) - restday 1 (day 11) - restday 2 (day 17) - last day of the Tour de France (day 23))