Investigation of Vascular Relaxing Effects of Candesartan and Pioglitazone.
- Conditions
- Healthy Subjects
- Registration Number
- NCT00154037
- Lead Sponsor
- Technische Universität Dresden
- Brief Summary
The study is designed to test the hypothesis in healthy subjects that candesartan and pioglitazone provide additional vascular relaxing or modulating effects in addition to their blood-pressure and blood glucose level reducing ability, respectively.
- Detailed Description
The aim of the study is to investigate the effect of oral candesartan and/ or rosiglitazone therapy on the vascular responsiveness of different vasoactive compounds (angiotensin II, insulin, histamine and glyceroltrinitrate) in healthy subjects. Pioglitazone will be given orally (4 weeks 30mg/d, titrated to 45 mg/d for another 4 weeks). Candesartan will be given orally (4 weeks 8mg/d, titrated to 16 mg/d for another 4 weeks) as treatment. Every subject will receive intravenous stimulation with phenylephrine, angiotensin II, histamine, insulin and glyceroltrinitrate before and after an 8 weeks treatment interval with study medication or placebo. In addition, pulse wave velocity will me measured non-invasively before and after treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 40
- Male
- healthy
- 18 - 40 years old
- non-smoker
- no additional medication
- any relevant disease
- smokers
- elevated liver enzymes
- body weight different from Broca Norm > 20%
- allergies
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Vascular reactivity
- Secondary Outcome Measures
Name Time Method Pulse wave velocity Changes in Angiotensin metabolites
Trial Locations
- Locations (1)
Institute of Clinical Pharmacology, Medical Faculty, University of Technology
🇩🇪Dresden, Germany