NCT02399683已完成不适用
Mucosal and Systemic Immune Modulation From Trichuris Trichiura in a Self-infected Individual
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1
- 主要终点
- Faecal egg excretion
研究概览
简要总结
Mucosal immunology during helminth infection
详细描述
The present study investigates the effects of Trichuris trichiura on human mucosal and systemic immunity in a single self-infected individual.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •The included volunteer is a researcher within parasitology with main focus on Trichuris trichiura and Trichiura suis. He planned to infect himself and contacted our department with the purpose of being monitored during this infection for safety (medical supervision) and research reasons. The only clinical criterion for his inclusion in the study was that he was healthy.
排除标准
- 未提供
结局指标
主要结局
Faecal egg excretion
时间窗: 30 weeks
Weekly monitoring of fecal egg counts by microscopy
次要结局
- Mucosal T cell associated cytokines(Week 15)
- Systemic immune parameters (eosinophilia, Subtypes of circulating T cells)(30 weeks)
- Adverse events(30 weeks)
研究者
Christian Hvas
MD, Ph.D.
University of Aarhus
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