The influence of preovulatory and postovulatory progesterone on the outcome of the in vitro fertilization (IVF)

Recruiting

• Conditions: Fertility problems among female patients and IVF outcome in terms of high preovulatory and postovulatory progesterone; Reproductive Health and Childbirth - Fertility including in vitro fertilisation

• Registration Number: ACTRN12615001315505
• Lead Sponsor: niversity Hospital Centre Zagreb, Department of Obstetrics and Gynaecology

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-12-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 400

Inclusion Criteria

Patients undergoing IVF treatment, patients with normal P4 values on the 2nd, 3rd and 4th day of the cycle, patients older then 18 years and younger then 37 years, normal responder patients (E2<3000 pg/ml, the number of oocytes <20) and high responder patients (E2>3000 pg/ml, the number of oocytes>20) will be included in the study.

Exclusion Criteria

Patients with elevated P4 on the 2nd, 3rd and 4th day of the cycle, women older than 37 years and poor responder patients (number of retrieved oocytes <4 on the day of hCG and E2 <500 pg/ml) will be excluded from the study since each of the above parameters adversely affects the IVF outcome.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the impact of the preovulatory P4 after the ovarian stimulation during the IVF treatment on the pregnancy outcome through the implantation and clinical pregnancy rate in normal responders and high responders with the fresh or frozen/thawed blastocysts transfer. This outcome will be assessed through the serum hCG assay and an ultrasound examination.[2 weeks after the embryo transfer]

Secondary Outcome Measures

Name	Time	Method
To analyze the IVF outcome in patients with elevated preovulatory P4 (>4.77 mmol/l) as compared to patients without high preovulatory P4.<br>The secondary outcome will be assessed through the ultrasound examination.<br>[6-8 weeks after the embryo transfer];To compare the IVF outcome in high responders with elevated preovulatory P4 through randomized fresh blastocyst and frozen/thawed blastocyst transfer in a natural cycle.<br>The secondary outcome will be assessed through the ultrasound examination.[6-8 weeks after the embryo transfer];To compare the IVF outcome in normal responders with elevated preovulatory P4 where the postovulatory level of P4 is lower than the mean P4 value on the 5th day of the cycle with fresh blastocyst transfer and the normal responders where the postovulatory P4 is higher than that determined value P4 with the frozen/thawed blastocyst transfer in the natural cycle.<br>The secondary outcome will be assessed through the ultrasound examination.[6-8 weeks after the embryo transfer]