Electronic monitoring of the use of antihypertensive drugs in patients with drug resistant hypertensio

Recruiting

Conditions: drugs, blood pressure, hypertension, compliance, treatment resistance, MEMS monitors

Registration Number: NL-OMON23458

Lead Sponsor: This is an investigator-driven study.Principal Investigator: prof. dr. P.W. de LeeuwCo-investigators: dr. P. Nelemans and dr. A.A. Kroon

Brief Summary: /A

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 150

Inclusion Criteria

Eligible are patients who have drug-resistent hypertension and have no renal artery stenosis (must have been excluded by conventional renal angiography or CT angiography or MR angiography).

Drug resistant hypertension is defined as having mean blood pressure >130/80 mm Hg according to 24-hour ambulatory blood pressure measurements (ABPM) despite the use of three or more drugs.

Exclusion Criteria

- Patient that do not meet the inclusion criteria

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome measure will be the proportion of patients who reach the target levels at 6 months after inclusion (question 1 and 2) and at one year after inclusion (question 3).

Secondary Outcome Measures

Name	Time	Method
Secondary outcome measures are: <br /><br>- The proportion of patients with substantial decrease in blood pressure (SBP > 10 mm Hg and/or DBP > 5 mm Hg)<br /> <br>- The compliance rate defined as percentage of days with correct number of dosing and prescribed number and doses of antihypertensive drugs.