The use of transexemic acid in total knee arthroplasty and incidence of venous thromboemboli

466 cases were identified. 85% of patients with a history of VTE and 87% of patients without a history of VTE received TXA intraoperatively. There was no significance in rate of post-operative VTE between patients given TXA vs those not given. Of the patients who received TXA, no patients with a history of VTE had a post-operative VTE (n=33) whilst ten patients without a history of VTE had a post-operative VTE (n=373). A multiple logistic regression model was used which did not demonstrate any significant difference between TXA use and VTE rate controlling for other independent variables. Our analysis found that there was a trend (p=0.06) towards males have a greater rate of VTE complications (4.6%) compared with females (1.7%). Independently there was a significant reduction in blood loss and transfusions. Iin patients who received routine TXA. Controlling for independent variables (age, sex, joint, BMI, ASA, Tourniquet use, IDC use), the subsequent reduction in blood loss and transfusion rate was still significant. ASA score was found to significantly increase the chance of transfusions but not blood loss.