Detection and Pathogenesis of Novel Protein F
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- Concentration of plasma protein F content
研究概览
简要总结
From December 6, 2019 to March 23, 2020, the research group of Qingkun Fan found a novel protein(temporarily named protein F) in heparin anticoagulant plasma of three patients with heart disease. One patient was diagnosed with multiple myeloma.However, protein F cannot be detected by serum protein electrophoresis. Preliminary studies have shown that this novel protein F have an obvious absorption peak at about 600nm. Placed at 2-8 degrees for 7 days, protein F will be isolated from heparin plasma. To the naked eye, protein F appear to be transparent jelly between the red blood cells and the plasma. The specific protein F, how it is produced, how it causes disease are still unknown. This study will explore how to detect protein F and how it is produced.
详细描述
Protein F screening was performed on anticoagulant blood plasma with heparin Lithium or blood serum by in-house turbidimetric method in Automatic biochemical analyzer.
All patients were followed-up for 3 years by telephones, routine appointment out-patient clinic or returning visit.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Testing total protein and albumin
- •Testing routine blood test
排除标准
- •high triglycerides (TG>5.00 mmol/L)
- •hyperbilirubinemia (TBIL>170 mmol/L)
- •fat emulsion used in past 3 days
- •patients with hemolytic disease
- •pregnant and lactating women
结局指标
主要结局
Concentration of plasma protein F content
时间窗: six month
the protein F content was measured by turbidimetric assay in automatic biochemical analyzer
次要结局
- Number of Participants with Multiple myeloma(3 years)