Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Functional Psychogenic Movement Disorders Followed by a Feasibility Study of a Hypnotherapy Treatment as Adjuvant Therapy.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Movement Disorders
- Sponsor
- University Hospital, Toulouse
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Changes of Psychogenic Movement Disorder Rating Scale (PMDRS= Hinson score between baseline and one month after rTMS treatment
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The management of functional psychogenic movement disorders (FNPMD) is challenging for neurologists and psychiatrists and only comprehensive multidisciplinary treatment programme can be worthwhile for these patients (Moene et al 2002). Recent functional magnetic resonance imaging studies have demonstrated abnormalities in motor control at cortical level, hyperactivity of limbic system and disturbance of connectivity between these two systems leading to a lack of self-agency, (Voon et al 2010,2011).Two recent studies suggested a possible therapeutic effect of transcranial magnetic stimulation (TMS) in FNPMD (Dakotakis 2011, Garcin, 2013).
In this protocol our objectives are twofold :
- to compare the effect of 5 consecutive daily sessions of rTMS on FNPMD in a double-blind randomized controlled study
- to study the effect of 3 weekly hypnosis sessions combined with rTMS in FNPMD
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Changes of Psychogenic Movement Disorder Rating Scale (PMDRS= Hinson score between baseline and one month after rTMS treatment
Time Frame: Inclusion and 1 month later
Secondary Outcomes
- Pain scale (VAS)(: inclusion, inclusion + 5 days, inclusion + 1 month, inclusion + 2 months, inclusion + 6 months, inclusion + 12 months.)
- Clinical Global Impression-Severity scale (CGI-SEVERITY/CGI-I/CGI-S)(inclusion, inclusion + 5 days, inclusion + 1 month, inclusion + 2 months, inclusion + 6 months, inclusion + 12 months.)
- Hospital Anxiety and Depression Scale (HAD/HDRS)(inclusion, inclusion + 1 month, inclusion + 6 months, inclusion + 12 months.)
- Quality of Life (SF-36)(inclusion, inclusion + 1 month, inclusion + 2 months, inclusion + 6 months, inclusion + 12 months.)
- Temperament and Character Inventory (TCI)(inclusion, inclusion + 12 months.)