Comparison of Effect of Airway Nebulization with 2% Lignocaine,nebulised 1mcg/kg dexmedetomidine and 0.25%Ropivacaine on Intubation and Extubation Response in Patients Undergoing Surgery under General Anesthesia

Phase 4

Not yet recruiting

• Conditions: asa status 1 and 2

• Registration Number: CTRI/2022/09/045292
• Lead Sponsor: srilakshmi narayana institute of medical sciences

Brief Summary

This study is Comparison of Effect of Airway Nebulization with Lignocaine 2%, nebulised dexmedetomidine 1mcg/kg and Ropivacaine 0.25%  on Intubation and Extubation Response in Patients Undergoing Surgery under General Anesthesia: A Randomized Double’Blind Clinical Trial with  Patient included from age 18-70 years of either sex posted for     Elective  surgery under general anesthesia with endotracheal intubation patients randomised in to three groups using block randomization.Group 1: Received Dexmedetomidine at a dose of 1 µg/kg mixed with saline to a total volume of 5 ml nebulization

• Group 2: Received 5 ml of 0.25% ropivacaine nebulization

• Group 3: Received 5 ml of 2% lignocaine via nebulization.

Drug was administered as aerosol through nebulization.MAP, HR, and SPO2 at;

• Baseline (T1)

• Upon tracheal intubation (T2)

• Upon anesthetic withdrawal (T3)

• Upon eye opening on verbal commands (T4)

• Upon tracheal extubation (T5)

• Two min after extubation (T6). were recorded and compared in this study

General parameters i.e. Age, Gender, weight, height and  Duration of surgery and duration of anesthesia.were compared and analysed.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-06-09
• Study Start: 2022-10-09

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Elective surgery under general anesthesia with endotracheal intubation cases.

Exclusion Criteria

• ASA 3 or more Patients with history of risk factors for perioperative aspiration of gastric contents, history of chronic obstructive pulmonary disease, asthma, history of recent respiratory infections, duration of surgery more than 3 h were excluded from the study.
• Pregnant and lactating mother Anticipated difficult airway.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
attenuation of intubation response	MAP, HR, and SPO2 at; | Baseline (T1) | Upon tracheal intubation (T2) | Upon anesthetic withdrawal (T3) | Upon eye opening on verbal commands (T4) | Upon tracheal extubation (T5) | Two min after extubation (T6).

Secondary Outcome Measures

Name	Time	Method
extubation response	up on end of surgery

Trial Locations

Locations (1)

srilakshmi narayana institute of medical sciences; 🇮🇳 Pondicherry, PONDICHERRY, India

srilakshmi narayana institute of medical sciences

🇮🇳Pondicherry, PONDICHERRY, India

elavanya

Principal investigator

09629181969

dr.lavanya08@gmail.com