Effects of Time Restricted Fasting and Exercise on Cardiovascular Risks Among Sedentary Adults
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sedentary; Aging
- Sponsor
- Guangzhou Sport University
- Enrollment
- 56
- Locations
- 1
- Primary Endpoint
- Change of cardiovascular risk estimated by ankle-brachial index
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This project will determine the independent and combined effects of aerobic exercise and time restricted fasting on cardiovascular risks among sedentary middle-aged and elderly adults. The online intervention period will be eight weeks. Before and after the intervention, arterial stiffness, cardiac autonomic nervous, body composition, glucolipid metabolism, sleep and eating habits, inflammatory reaction, sedentary behavior and physical activity level will be measured and compared between groups who are doing either aerobic exercise, time restricted fasting, both aerobic exercise and time restricted fasting, or who are in a control group. Adverse reaction, sleep and eating quality, life quality and adherence to the interventions and hunger/satiety will also be measured.
Investigators
Jingwen Liao
Associate Professor
Guangzhou Sport University
Eligibility Criteria
Inclusion Criteria
- •Age: 45-69 years old Sedentary time ≥8 hours per day
- •Irregular exercise habits
- •No drugs affecting the outcome index were taken
- •No history of serious diseases
- •Sign the subject informed consent and agree to participate in this experiment.
Exclusion Criteria
- •The range of body weight change in the last three months is more than 3kg
- •People taking weight-loss drugs
- •Participate in other experimenters 5 months before the experiment
- •Unable to adjust and follow the intervention schedule.
Outcomes
Primary Outcomes
Change of cardiovascular risk estimated by ankle-brachial index
Time Frame: From baseline to after 8 weeks intervention
Change of cardiovascular risk estimated by heart rate variability
Time Frame: From baseline to after 8 weeks intervention
Change of cardiovascular risk estimated by pulse wave velocity
Time Frame: From baseline to after 8 weeks intervention
Change of cardiovascular risk estimated by flow-mediated transition
Time Frame: From baseline to after 8 weeks intervention
Change of cardiovascular risk estimated by cytokines level
Time Frame: From baseline to after 8 weeks intervention
Fasting matrix metalloproteinases, norepinephrine, and neuropeptide Y cytokines level in blood
Secondary Outcomes
- Sleep quality(From baseline to after 8 weeks intervention)
- Physical activity(From baseline to after 8 weeks intervention)
- Weight(From baseline to after 8 weeks intervention)
- body fat(From baseline to after 8 weeks intervention)
- Diet habits(From baseline to after 8 weeks intervention)
- Triglycerides in blood(From baseline to after 8 weeks intervention)
- Adherence to intervention(From baseline to after 8 weeks intervention)
- Lean body mass(From baseline to after 8 weeks intervention)
- Body fat percentage(From baseline to after 8 weeks intervention)
- Life quality(From baseline to after 8 weeks intervention)
- Cholesterol in blood(From baseline to after 8 weeks intervention)
- Diet in take(From baseline to after 8 weeks intervention)
- Body mass Index(From baseline to after 8 weeks intervention)
- Low density lipoprotein in blood(From baseline to after 8 weeks intervention)
- Sedentary activity(From baseline to after 8 weeks intervention)
- Inflammation level(From baseline to after 8 weeks intervention)
- High density lipoprotein in blood(From baseline to after 8 weeks intervention)
- Adverse reaction(From baseline to after 8 weeks intervention)