Neoadjuvant Chemotherapy Combined With Preoperative Radiotherapy for Locally Advanced Breast Cancer
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 主要终点
- pathological complete respons
研究概览
简要总结
Approximately 20% of breast cancer patients in our country are in the locally advanced stage. The relatively low overall survival rate, high recurrence rate and distant metastasis risk of these patients significantly affect the therapeutic efficacy and survival. Preoperative radiotherapy is a treatment option for many tumors. It is recommended to administer radiotherapy and systemic chemotherapy before surgery to enhance preoperative tumor downstaging, eliminate micrometastatic lesions and improve overall survival rate. Preoperative radiotherapy combined with chemotherapy for breast cancer patients further shrinks the tumor, increases the probability of breast preservation, and may also eliminate the need for axillary lymph node dissection, thereby improving the quality of life of patients. Pathological complete response (pCR) not only helps with subsequent surgery but also has significant advantages in improving survival rate. Neoadjuvant radiotherapy is also one of the treatment options for reducing tumor stage, but it has not been widely applied to breast cancer patients. Among breast cancer subtypes, Luminal type accounts for 50-70%, among which HR+ HER2- breast cancer patients have poor efficacy from neoadjuvant chemotherapy and pCR rate is below 5-10%. Triple-negative breast cancer accounts for 15-20% of all breast cancer subtypes. It has the characteristics of poor differentiation, strong invasiveness, earlier and more frequent recurrence and metastasis. The efficacy of traditional neoadjuvant chemotherapy has approached its limit. This study aims to explore the efficacy and safety of neoadjuvant radiotherapy for locally advanced breast cancer.
详细描述
Approximately one fifth of the patients in China have non-metastatic locally advanced breast cancer. Due to their relatively low overall survival rate, high recurrence rate, and risk of distant metastasis, this significantly affects the therapeutic efficacy and survival of the patients. Preoperative neoadjuvant radiotherapy is a common treatment option for many tumors (such as esophageal cancer, rectal cancer, soft tissue sarcoma, etc.), by advancing radiotherapy and systemic chemotherapy to before surgery to enhance preoperative treatment for tumor downstaging and early elimination of micrometastatic lesions to improve overall survival rate. In breast cancer patients, preoperative radiotherapy combined with chemotherapy has the opportunity to further shrink the tumor, increase the probability of breast preservation, and possibly avoid axillary lymph node dissection, thereby improving the quality of life of the patients. Pathological complete response (pCR) not only helps subsequent surgical treatment but also has significant advantages in improving survival rate, significantly improving the overall prognosis of patients. Neoadjuvant radiotherapy is also one of the treatment options for reducing the stage. However, this combination has not been widely applied to breast cancer patients yet and further clinical research is needed. Among all breast cancers, Luminal-type breast cancer accounts for 50-70%, among which patients with HR+HER2- type breast cancer have poor efficacy of neoadjuvant chemotherapy and the pCR rate is usually below 5-10%. Triple-negative breast cancer accounts for 15-20% of all breast cancer subtypes, characterized by poor differentiation, strong invasiveness, earlier and more frequent recurrence and metastasis. The efficacy of traditional neoadjuvant chemotherapy has approached its limit and the pCR rate hovers around 35%. This study aims to explore the pCR rate, effectiveness and safety of preoperative chemotherapy combined with preoperative medium-dose fractionated radiotherapy in patients with locally advanced HR+HER2- type and triple-negative breast cancer, to improve the overall survival of these patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •The pathological diagnosis was invasive breast cancer.
- •cT3-4, cN1-2, M0 (according to the 8th edition of the AJCC Cancer Staging Manual), molecular typing is Luminal type (HER2-) or triple-negative type. The volume of the primary lesion did not decrease by more than 50% after 2 cycles of neoadjuvant chemotherapy.
- •Generally in good condition (KPS score > 70), organ functions are tolerable, and there are no severe complications due to poor control.
- •Acceptable for magnetic resonance imaging scan
- •Have the conditions for follow-up
- •Sign the informed consent form
排除标准
- •gestation period
- •Simultaneous bilateral breast cancer
- •History of chest wall radiotherapy
- •Active connective tissue disease
- •Inflammatory breast cancer
- •Excessive breast volume (>600ml), BMI > 30
- •Positive lymph nodes in the upper and lower regions of the clavicle and the internal mammary region
- •Using immunotherapy drugs such as PD-1/PD-L1
研究组 & 干预措施
preoperative radiotherapy
whole breast irradiation of the affected side ± chest wall + regional lymph node drainage area irradiation: whole breast ± chest wall + supraclavicular and internal mammary regional lymph node drainage area 40.05Gy/152.67Gy/ day per session, axillary regional lymph node drainage area 37.5Gy/15f,2.5Gy/ per session
干预措施: preoperative radiotherapy (Radiation)
结局指标
主要结局
pathological complete respons
时间窗: 8-12 weeks
pathological complete
次要结局
未报告次要终点
研究者
JIN JING
Principal Investigator
Cancer Institute and Hospital, Chinese Academy of Medical Sciences