Clinical Efficacy of Amoxicillin Given Twice or Three Times a Day Among Children With Non-severe Pneumonia
- Registration Number
- NCT01200706
- Lead Sponsor
- Federal University of Bahia
- Brief Summary
The purpose of the study is to compare the clinical efficacy of amoxicillin given twice or three times a day to children with non-severe community-acquired pneumonia.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 820
Inclusion Criteria
- Children aged between 2 and 59 months
- Report of respiratory complaints
- Presence of pulmonary infiltrate on chest x-ray taken on admission and read by the pediatrician on duty
Exclusion Criteria
- lower chest indrawing
- danger signs (inability to drink, convulsions, somnolence, central cyanosis, grunting in a calm child)
- diagnosed underlying chronic diseases (anatomic abnormalities of the respiratory tract, chronic pulmonary illness besides asthma, immunological defects, progressing neurological disorders, psychomotor retardation, heart disease with clinical repercussion, hemoglobinopathy, liver or kidney disease)
- severe malnutrition
- other concurrent infection
- hospitalization during the previous 7 days
- amoxicillin or similar antibiotic use during the last 48 hours
- allergy to amoxicillin
- history of aspiration
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Amoxicillin given twice a day Amoxicillin - Amoxicillin given three times a day Amoxicillin -
- Primary Outcome Measures
Name Time Method clinical efficacy 48 hours resolution of fever, difficulty breathing and tachypnea
- Secondary Outcome Measures
Name Time Method Resolution of cough 96 hours Disappearance of cough
Trial Locations
- Locations (1)
Professor Hosannah de Oliveira Pediatric Center
🇧🇷Salvador, Bahia, Brazil