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临床试验/CTRI/2025/07/092101
CTRI/2025/07/092101尚未招募2 期

A clinical control study of gunjadi varti and ghoshaphala varti in the management of abhyantar guda arsha (2nd degree haemorrhoid)

Dr Mayuri Ramchandra Makode1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2025年8月16日最近更新:

试验速览

阶段
2 期
状态
尚未招募
发起方
入组人数
70
试验地点
1
主要终点
Number of arshankur(haemorrhoids)

研究概览

简要总结

To compare the efficacy of Gunjadi varti and Ghoshaphala varti in the management of abhyantar guda arsha (2nd degree haemorrhoid)

It has become notorious to manage Arsha through surgical procedure due to post-operative pain associated with many more complications. Also, surgery is not possible in many cases like extremes of age, surgically unfit persons, pregnancy. Both modern and ancient Indian system of medicine mentioned conservative (bheshaja) treatment for foremost Consideration. Ayurveda advocated equal importance to sthanik chikitsa along with bheshaja chikitsa in the form of lepa (creams/ointments), avagahan (fomentation), parishek (sprinkling), raktamokshan (bloodletting), abhyanga (local massage), Dhupan (Fumigation). Other than many oral medications for symptomatic treatment in Arsha, patients mostly need and ask medicine for local application for instant relief, mental satisfaction and avoidance of oral preparations due to fear of gastric troubles & bad taste of some medicines especially herbal preparations. Herbal and contemporary ointments for local application available in the pharmacy for the management of haemorrhoids have plastic applicators which while application sometimes make trauma/hurt inside the anal canal. So, when medicine has to be applied internally in internal hemorrhoids Gudavarti or rectal suppository must be a better option to avoid trauma and also it is easy for the patient to administer it by self at home. Varti Kalpana has been mentioned in almost all the Ayurvedic treatises viz. Charaka samhita, Sushruta Samhita, Ashtanga hridaya, Rasarathna samucchaya, Bhaishajya ratnavali, and Chakradatta. Bhaishajya ratnavali widely contributes different Guda Vartis in different diseases. It has been used to attain quick relief from conditions like Udavarta, Mutrkriccha, Baddha Koshta, Shula, Basti vyapad, Arsha. It causes vayu anulomana which results in the elimination of mala and mootra along with the removal of sanchitha rakta sleshma pooya dosas. Contemporary Suppositories are the modified form of ancient Varties. Rectal suppositories are used to produce local action at the site of application but many of them are used to produce systemic actions. Presently most common rectal suppository used in the management of hemorrhoidal disease is corticosteroid based (eg. hydrocortisone) along with anesthetic (eg. lidocaine), emollient (eg. allantoin), protectant & astringent (eg. zinc oxide). Medicinal herbs have numerous bioactive molecules & could be traced for their therapeutic potentials and converted into various dosage forms for convenience in treatment. Recent advances hence could be utilized for moulding Varti into suppository and enhancing the scope of therapeutic dosage forms.

Conclusion:  Gudavarti causes vatanuloman & removes sanchitha rudira, stambha, shoola, kandu, shwayathu in arshas. It treats arshas from its roots (Arsh samoola nivratheye). Hence, it could be used as a safe, simple & efficacious first line treatment along with oral medications in the Management of arsha.

研究设计

研究类型
Interventional
分配方式
Coin toss, Lottery, toss of dice, shuffling cards etc
盲法
None

入排标准

年龄范围
20.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • 1.Patient having 2nd degree haemorrhoids.
  • 2.Selection of patient will be done irrespective of sex ,religion and socioeconomic class.

排除标准

  • Patient having 3rd & 4th degree haemorrhoids.
  • Patient having CA Rectum & anal canal.
  • Pregnancy.
  • Patient having DM, HTN, HIV, HBsAG, Tuberculosis or any other systemic disorder.

结局指标

主要结局

Number of arshankur(haemorrhoids)

时间窗: Weekly upto 28 days

Bleeding.

时间窗: Weekly upto 28 days

Efficacy of Gunjadi Varti and Ghoshaphala Varti in reducing key symptoms of abhyantar guda arsha (2nd degree haemorrhoids) over a period of 28 days, assessed both subjectively and objectively.

时间窗: Weekly upto 28 days

Subjective parameters:

时间窗: Weekly upto 28 days

Vedana(pain)

时间窗: Weekly upto 28 days

Toda(pricking pain)

时间窗: Weekly upto 28 days

Kandu(itching)

时间窗: Weekly upto 28 days

Malavbaddhata(constipation)

时间窗: Weekly upto 28 days

Colour of pile mass

时间窗: Weekly upto 28 days

Objective criteria:

时间窗: Weekly upto 28 days

次要结局

  • Overall symptom relief grading(Excellent greater than 75 percent relief)

研究者

发起方
Dr Mayuri Ramchandra Makode
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Dr Mayuri Ramchandra Makode

Ashvin Rural Ayurved College and Hospital, Sadhvi Preetisudhaji Maharaj Nagar, Manchi Hill, Ashvi Bk, Tal.Sangamner, Dist.Ahmadnagar

研究点 (1)

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