The Effect of High-intensity Interval Training and Moderate Intensity Continuous Training on Cardiopulmonary Functions in Chronic Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Maximal or peak oxygen consumption (VO2max or VO2peak, same meaning) (kg/ml/min)
研究概览
简要总结
The aim of this study is to investigate the effect of high-intensity interval training and moderate intensity continuous training on cardiopulmonary functions in chronic heart failure.
详细描述
enroll chronic heart failure patients into 3 randomized controlled group
- high intensity interval training
- moderate intensity continous training
- control
perform cardica rehab for 12 weeks, compare primary and secondary endpoints between baseline and 12 weeks results
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •medically stable chronic heart failure
- •NYHA II-III
- •can perform cardiopulmonary exercise test
- •after 3months with proper medication
- •age 30 to 70
- •ejection fraction< 40%
排除标准
- •contraindication to cardiopulmonary exercise test
- •musculoskeletal problem who cannot perform cardiopulmonary exercise test
- •cognition deficit who cannot understand directions
- •severe medial illness
研究组 & 干预措施
Moderate intensity continous training
干预措施: Cardiac rehabilitation comprised aerobic exercise on a treadmill accompanied by an electrocardiogram monitoring device and a blood pressure monitor (Behavioral)
Control
干预措施: Cardiac rehabilitation comprised aerobic exercise on a treadmill accompanied by an electrocardiogram monitoring device and a blood pressure monitor (Behavioral)
High intensity interval training
干预措施: Cardiac rehabilitation comprised aerobic exercise on a treadmill accompanied by an electrocardiogram monitoring device and a blood pressure monitor (Behavioral)
结局指标
主要结局
Maximal or peak oxygen consumption (VO2max or VO2peak, same meaning) (kg/ml/min)
时间窗: compare baseline data with 12 weeks rehabilitation data
at the end of training, from baseline to 12 weeks
次要结局
- 6minute walk test (meter)(compare baseline data with 12 weeks rehabilitation data)
- Anaerobic threshold (kg/ml/min)(compare baseline data with 12 weeks rehabilitation data)
- maximal heart rate (bpm)(compare baseline data with 12 weeks rehabilitation data)
- systolic blood pressure (mmHg)(compare baseline data with 12 weeks rehabilitation data)
- diastolic blood pressure (mmHg)(compare baseline data with 12 weeks rehabilitation data)
- resting heart rate (bpm)(compare baseline data with 12 weeks rehabilitation data)
- diastolic blood presure (mmHg)(compare baseline data with 12 weeks rehabilitation data)
- depression scale by Patient Health Questionnaire(compare baseline data with 12 weeks rehabilitation data)
- anxiety scale by Generalized Anxiety Disorder Scale(compare baseline data with 12 weeks rehabilitation data)
- fatigue scale by fatigue severity scale(compare baseline data with 12 weeks rehabilitation data)
- Quality of Life (QoL) questionnaire (MacNew)(compare baseline data with 12 weeks rehabilitation data)
研究者
Joa KyungLim
professor, M.D. Ph.D
Inha University Hospital