Ayurvedic medications in the treatment of Knee Osteoarthritris

Phase 2

Conditions: Health Condition 1: M179- Osteoarthritis of knee, unspecified

Registration Number: CTRI/2022/12/048232

Lead Sponsor: Dr Oshin Sharma

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1 Individuals aged between 40 years to 70 years

2 Subjects with Signs and Symptoms of Sandhigatavata as per Ayurvedic classics

3 Subjects fulfilling the diagnostic criteria & diagnosed previously (As per American college of Rheumatology (ACR) classification criteria for OA of the Knee)

4 Affected knee joint - Single or Both

5 Pain in the knee joints greater than or equal to 3 months

6 Patients of Either Sex

Exclusion Criteria

1 Patients with Severe arthritis (KL grade IV)

2 Gross disability like bedridden and confined to wheel chair

3 Patients with RA, Gout, Osteoporosis and other Musculoskeletal system disorders

4 Patients with other major systematic disorders which interfere with the treatment will be excluded like uncontrolled DM (FBS >130 mg/dL, PPBS > 250 mg/dL, HbA1C > 8.5%) and Hypertension > 160/100 mm of Hg

5 Patients with ligamental or any other knee joint injury

6 Patients with history of Knee surgery

7 Use of NSAIDs, Analgesics, Intra articular steroid injections within the past period of 30 days.

8 Pregnant or lactating women

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome will be VAS and WOMAC Scale in Knee osteoarthritis in 60 days.Timepoint: Baseline, 15th, 30th, 45th and 60th day

Secondary Outcome Measures

Name	Time	Method
Secondary Outcome of Knee Osteoarthritis on the basis of WHOQOL-BREF Scale, Goniometry of Knee Joint, Walking Velocity & Interleukin-6 (IL-6)Timepoint: WHOQOL-BREF Scale – On Baseline, 15th, 30th, 45th, & 60th day <br/ ><br>Goniometry of Knee Joint- On Baseline, 15th, 30th, 45th, & 60th day <br/ ><br>Walking velocity- On Baseline, 15th, 30th, 45th, & 60th day <br/ ><br>Interleukin 6 (IL-6)- On Baseline & 60th day