The Influence of NPPA/NPPB Haplotype on Natriuretic Peptide Plasma Levels
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 437
- 试验地点
- 1
- 主要终点
- Influence of NPPA/NPPB haplotype on natriuretic peptide plasma levels
研究概览
简要总结
Crosssectional study to analyse the genetic influence on levels of cardiac biomarkers (BNP, NT-proBNP).
详细描述
Background
Natriuretic peptides play an important role in risk stratification and management of patients undergoing non-cardiac surgery. However, due to genetic variability, the levels of these biomarkers may differ in individual patients with cardiac derangement. In the preoperative setting, genetic contribution to natriuretic peptide plasma level variability has not yet been determined.
Objective
The aim of this study is to assess genetic contribution to NP plasma level variability in a Swiss cohort.
Methods
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 years and older
- •Written informed consent
- •Scheduled surgery
- •Exclusion Criteria
- •No informed consent
- •Cognitive impairment
排除标准
- 未提供
结局指标
主要结局
Influence of NPPA/NPPB haplotype on natriuretic peptide plasma levels
时间窗: Blood samples collected at start of anesthetic procedure
Estimation of genetic effects on natriuretic peptide (BNP, NT-proBNP) plasma levels
次要结局
未报告次要终点