The Influence of NPPA/NPPB Haplotype on Natriuretic Peptide Plasma Levels

Completed

• Conditions: Anesthesia; Surgical Procedure, Operative

• Registration Number: NCT04327258
• Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Brief Summary

Crosssectional study to analyse the genetic influence on levels of cardiac biomarkers (BNP, NT-proBNP).

Detailed Description

Background

Natriuretic peptides play an important role in risk stratification and management of patients undergoing non-cardiac surgery. However, due to genetic variability, the levels of these biomarkers may differ in individual patients with cardiac derangement. In the preoperative setting, genetic contribution to natriuretic peptide plasma level variability has not yet been determined.

Objective

The aim of this study is to assess genetic contribution to NP plasma level variability in a Swiss cohort.

Methods

Cross-sectional association study in a cohort of non-cardiac surgery patients.

This study is a Subproject of a prospective cohort study registered under the ID 041/09.

Study Timeline

• Study Start: 2011-01
• Primary Completion: 2014-12
• Study Completion: 2014-12
• Status Verified: 2020-03
• Study First Submitted: 2020-03-26
• Study First Submitted QC: 2020-03-26
• Last Update Submitted: 2020-03-26
• Study First Posted: 2020-03-31
• Last Update Posted: 2020-03-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 437

Inclusion Criteria

• 18 years and older
• Written informed consent
• Scheduled surgery

Exclusion Criteria

• No informed consent
• Cognitive impairment

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Influence of NPPA/NPPB haplotype on natriuretic peptide plasma levels	Blood samples collected at start of anesthetic procedure	Estimation of genetic effects on natriuretic peptide (BNP, NT-proBNP) plasma levels

Trial Locations

Locations (1)

Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern; 🇨🇭 Bern, Switzerland