Fluor Varnish With Silver Nanoparticles for Dental Remineralization in Patients With Trisomy 21
Phase 2
- Conditions
- Down Syndrome
- Interventions
- Drug: Fluor varnishDrug: Fluor varnish with nanoparticles
- Registration Number
- NCT01975545
- Lead Sponsor
- Universidad Autonoma de San Luis Potosí
- Brief Summary
Patients with trisomy 21 are in greater danger of developing caries. It has been hypothesized that adding silver nanoparticles to fluor varnishes could promote remineralization of the teeth. A split-plot randomized controlled trial will be performed to address this question.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Patients with trisomy 21 diagnosed through caryotype
- Age 1 to 6 years old
- Any sex
- White spot present in both upper anterior teeth
- Parental agreement to participate in the study
Exclusion Criteria
- Hypersensibility to any of the substances used
- Non cooperating patients
- Caries in enamel or dentine in the upper anterior teeth
- Leukemia or diabetes
- Dental fluorosis present
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Fluor varnish Fluor varnish Fluor dental varnish (Fluor Protector, Ivoclar Vivadent, Principality of Liechtenstein) Fluor varnish with nanoparticles Fluor varnish with nanoparticles Fluor dental varnish (Fluor Protector, Ivoclar Vivadent, Principality of Liechtenstein) plus 25% 50 nm silver nanoparticles.
- Primary Outcome Measures
Name Time Method Remineralization 3 months Remineralization status will be assessed through laser fluorescence of the tooth with a Diagnodent probe (Diagnodent, Kavo, Madrid, Spain)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Universidad Autónoma de San Luis Potosí
🇲🇽San Luis Potosí, Mexico