Genicular Nerve Phenol Neurolysis Versus Radiofrequency Ablation for Pain Relief in Grade 4 Knee Osteoarthritis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Ain Shams University
- Enrollment
- 114
- Primary Endpoint
- Numeric rating scale
Study Overview
Brief Summary
The goal of this clinical trial is to compare the efficiency and efficacy of genicular nerves blockade by chemical phenol neurolysis versus radiofrequency ablation in managing pain in patients suffering from grade IV KOA in term of NRS pain score.
The participants will be evaluated by numeric rating scale and oxford knee score for assessment of pain relief up to 16 weeks.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Grade 4 knee osteoarthritis according to Kellgren-Lawrence radiological classification.
- •Failure to manage pain with conservative methods.
Exclusion Criteria
- •Prior knee replacement
- •Patients with cardiac pacemakers or implantable cardiac defibrillators.
- •Septic knee or systemic sepsis.
- •Allergy to any of the drugs used in the study.
- •Coagulopathy or patients on anticoagulants.
- •Patients with psychiatric illness.
Arms & Interventions
genicular nerve phenol neurolysis
chemical neurolysis using 2 mL of 9% phenol solution prepared from crystallized phenol will be applied to each genicular nerve.
Intervention: genicular nerve neurolysis (Procedure)
genicular nerve radiofrequency ablation
Radiofrequency thermocoagulation will be applied to each nerve at 80 degrees for 90 seconds.
Intervention: genicular nerve neurolysis (Procedure)
Outcomes
Primary Outcomes
Numeric rating scale
Time Frame: baseline, 2, 4, 8,12 and 16 weeks after the procedure
By an independent physician pain will be recorded using numeric rating scale which is a screening tool used to assess pain severity using a 0 - 10 scale with zero meaning no pain and 10 meaning the worst pain ever.
Secondary Outcomes
- oxford knee score(baseline, 4, 8, 12, 16 weeks after the procedure)