The Association of Diabetes Mellitus and Inflammatory Bowel Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- effect of IBD on DM
研究概览
简要总结
Diabetes mellitus is a hyperglycemic metabolic disorder due to insulin deficiency or resistance at its receptors, leads to impaired glucose metabolism and multi-organ affection; (optic, peripheral neurological, cardiovascular and renal).
详细描述
Inflammatory bowel disease; (Crohn's disease and ulcerative colitis), is chronic relapsing inflammation in the gastrointestinal tract due to complex interactions among genetic, environmental, gut microbiome, and immunologic factors.
Inflammatory bowel disease treatment inhibits the abnormal inflammatory response to heal intestinal tissue, relieve the abdominal pain, the diarrhea and the fresh bleeding per rectum, also decreases the frequency of flare-ups and maintains remission.
Amino-salicylates and antibiotics are step I drugs act on the intestinal lining and on presented inflammatory masses.
Corticosteroids are step II drugs on failure of step I drugs for adequate control of the Inflammatory bowel disease and rapid relief of symptoms and inflammation.
The immune modifying agents as azathioprine and 6 mercaptopurine are step III drugs on failure of the steroids.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients with IBD admitted at EL-Raghy Assiut university hospital in the period of first of October 2019 to the end of September 2020 The diagnosis of DM is confirmed by high random blood glucose level more than 200mg/dl three times per day or high HbA1c more than 6.5%.
- •The diagnosis of IBD is confirmed by colonic biopsy results after colonoscopy.
排除标准
- •Patients didn't do colonoscopy or didn't get biopsy or with normal colonoscopy and biopsy
结局指标
主要结局
effect of IBD on DM
时间窗: on addmision
patients with raised; HbA1c, fasting blood glucose, 2 hours postprandial blood glucose
次要结局
未报告次要终点
研究者
MM Youssif
principal investigator
Assiut University