Intravenous Dexamethasone on Postoperative Pain and Complications in Jaw Surgery

Phase 4

Completed

• Conditions: Tooth Extraction Status Nos; Cysts Dental; General Anesthesia
• Interventions: Drug: Dexamethasone

• Registration Number: NCT06787196
• Lead Sponsor: Selcuk University

Brief Summary

This study aims to evaluate the effect of single-dose intravenous dexamethasone on postoperative pain and other complications in compacted tooth and cyst enucleation procedures performed under general anesthesia.

Detailed Description

During surgery, patients were carefully monitored with standard equipment to track oxygen levels (SpO2), heart activity (ECG), blood pressure, and carbon dioxide levels. General anesthesia was started with medications like thiopental, rocuronium, and fentanyl, and maintained with a mix of oxygen, air, sevoflurane, and remifentanil. Patients were intubated with appropriate tubes, and the surgical team applied a local anesthetic (Articaine with Epinephrine) to the area before starting the procedure. After the surgery, patients were given dexamethasone (DXM) and pantoprazole intravenously, then safely extubated and sent to recovery. All patients were discharged on the same day.

Postoperative recovery was assessed using pain scores (VAS) and physical evaluations. Pain levels were categorized as mild, moderate, or severe, and an analgesic was provided if the score exceeded 3. Facial swelling was measured by comparing pre- and post-surgery facial landmarks, with swelling classified into grades based on the percentage of change. Mouth opening was evaluated with a caliper to check for trismus (jaw stiffness), with results grouped into normal, mild, moderate, or severe grades depending on the degree of restriction. Follow-ups were conducted by an independent clinician on postoperative days 1, 2, and 7.

Study Timeline

• Study Start: 2024-01-01
• Study First Submitted: 2024-12-27
• Study First Submitted QC: 2025-01-16
• Study First Posted: 2025-01-22
• Primary Completion: 2025-01-31
• Study Completion: 2025-01-31
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-12
• Last Update Posted: 2025-05-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• ASA physical status I-II
• underwent split-mouth surgery

Exclusion Criteria

• Patients undergoing corticosteroid therapy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Dexamethasone	Dexamethasone	At the end of the procedure, patients received a single IV dose of Dexamethasone (0.1 mg/kg) before being extubated.

Primary Outcome Measures

Name	Time	Method
IV dexamethasone (DXM) changes postoperative complications	6 months	Postoperative pain, swelling, and restricted mouth opening are identified as key postoperative concerns. The anti-inflammatory effects of dexamethasone (DXM) are utilized to address these complications.

Trial Locations

Locations (1)

Funda Arun; 🇹🇷 Selçuklu, Konya, Turkey