The Relationship Between Renal Functions and Multi Drug Resistant Organisms in Patients With Ventilator Associated Pneumonia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 133
- 试验地点
- 1
- 主要终点
- Multi-drug resistant (MDR) pneumonia
研究概览
简要总结
Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in patients receiving invasive mechanical ventilation (MV). Antibiotic resistance poses an increasing threat due to the rise of infections caused by multidrug-resistant organisms (MDROs).Despite the increase in the frequency of MDRO colonisation and infection in dialysis patients, it is not known enough whether the risk of multi-drug resistant (MDR) pneumonia increases in mild-to-severe chronic kidney disease (CKD) (eGFR <60 mL/min/1.73 m2) patients not receiving dialysis. Therefore, in our study, the investigators aimed to evaluate the relationship between renal functions and MDR VAP risk and the specific microbial pattern.
详细描述
This prospective observational study was performed on adult patients intubated and receiving MV for at least 48 hours in the 42-bed surgical and medical Intensive Care Unit. The study was conducted between August 2019 and January 2021 and approved by the Ethics Committee of Necmettin Erbakan University Medical School. Informed consents were obtained from patients participating in the study or from their relatives. The characteristics of patients with MDRO infection associated with different eGFR categories in VAP patients were recorded.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of 18 years of age and above
- •A clinical suspicion of VAP as defined in the American Thoracic Society (ATS) guidelines
- •A Clinical Pulmonary Infection Score (CPIS) > 6
- •No signs and symptoms of infection at the time of admission to the ICU
排除标准
- •Acute kidney injury
- •Renal replacement treatment (RRT)
- •Renal transplantation
- •Active tuberculosis
- •Malnutrition
- •Immunosuppression (neutropenia, HIV positivity, transplantation, prednisone treatment of ≥20 mg/day, etc.)
- •Any extrapulmonary infection other than VAP at the time of being included in the study
- •Respiratory cultures presented fungal agents
- •Normal flora
- •No growth
结局指标
主要结局
Multi-drug resistant (MDR) pneumonia
时间窗: 18 months
The presence of an infection with a resistant pathogen in patients with impaired renal function (eGFR \<60 mL/min/1.73 m2) served as our primary outcome measure
次要结局
未报告次要终点
研究者
Omur ILBAN
Principal investigator
Konya Numune Hospital