DRKS00013497
Completed
Not Applicable
Study on the incidence of genetic polymorphism in patients with major depression who are treated unsatisfactory with antidepressants - GENADET
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Genetic polymorphism of drug metabolizing
- Sponsor
- STADAPHARM GmbH
- Enrollment
- 252
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Outpatients with a diagnosis of major depression
- •First drug treatment with one of the following active substances since max. two weeks:
- •\-Citalopram
- •\-Escitalopram
- •\-Amitriptyline
- •\-Venlafaxine
- •Age \=18 years
- •Capacity to consent
Exclusion Criteria
- •Comedication with influence on the activity of the enzymes CYP2C19 and CYP2D6
- •Intake of St. John's wort preparations
- •Consumption of grapefruit and / or products
- •Consumption of tryptophan\-containing dietary supplements
- •Change of medication within the last 3 months
- •Hepatic insufficiency (from Child\-Pugh\-stage A)
- •Renal insufficiency stage 3 (glomerular filtration rate \<60 ml / min / 1\.73 m²)
- •Addiction
- •Schizophrenia
- •Bipolar affective disorder
Outcomes
Primary Outcomes
Not specified
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