The potential of food processing technologies to improve bioavailability of carotenoids from carrots-a pilot study in volunteers with ileostomy

Not Applicable

• Conditions: bioavailability of phytochemicals, in particular carotenoids from foods (carrots) of varying but controlled particle size; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12609000947202
• Lead Sponsor: Food Futures Flagship- Nutrient release and Bioavailability Stream

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-11-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

conventional and well-functioning permanent ileostomy

Exclusion Criteria

Use of any form of drug therapy or medication or supplements that may interfere with bowel function eg antibiotics
Definite or suspected personal history or family history of adverse events or intolerance of plant-based foods being tested in this study
Persons considered by the investigator to be unwilling, unlikely or unable to comprehend or comply withthe study protocol and restrictions
Persons unwilling or unable to collect ileal effluent as required
Paticipants taking any supplements which could interfere with study parameters

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
determination of the % of carotenoids absorbed by mass calculation[ileal samples collected at 7am on day 1 of each trial period and there after at 2 hr intervals until ~11pm at night. This pattern is replicated for the 4 days of each trial period ie a total of 9 collections for each day from Monday 7am to Friday 7am for each of 2 weeks]

Secondary Outcome Measures

Name	Time	Method
microscopy of ileal digesta[ileal samples collected at 7am on day 1 of each trial period and there after at 2 hr intervals until ~11pm at night. This pattern is replicated for the 4 days of each trial period ie a total of 9 collections for each day from Monday 7am to Friday 7am for each of 2 weeks];Time course of carrot digestion and flow to the ileal collection[ileal samples collected at 7am on day 1 of each trial period and there after at 2 hr intervals until ~11pm at night. This pattern is replicated for the 4 days of each trial period ie a total of 9 collections for each day from Monday 7am to Friday 7am for each of 2 weeks]