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Randomized, Multicenter, Phase III Trial to Assess Conformal Post-operative Radiotherapy vs. Surveillance After Complete Resection of Stage II/III Thymoma

Not Applicable
Recruiting
Conditions
Thymoma Malignant Recurrent
Interventions
Other: Radiotherapy
Other: Surveillance after resection
Registration Number
NCT04731610
Lead Sponsor
Institut Curie
Brief Summary

The primary objective of the study : to compare the Recurrence-Free survival (RFS) between arms. RFS is defined as time from randomisation to the first recurrence (either local-regional or distant) or death of any cause.

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
314
Inclusion Criteria
  1. 18 < Age < 75 years old
  2. ECOG performance status ≤1
  3. Preoperative chemotherapy is allowed. Maximum of 4 cycles are authorized. Surgery should be realized ≤ 2 months after the last chemotherapy injection.
  4. Histologically diagnosed thymoma at pathological examination of surgical specimen after pathological review; for note, centralized, real-time, systematic pathological review is standard through the RYTHMIC network in France
  5. Complete resection at pathological examination of the surgical specimen after surgery conducted through standard, recommended approach ensuring accurate assessment of resection status
  6. Stage IIb or III disease according to the Masaoka-Koga staging system; this corresponds to stage pT1a with capsule invasion, until stage pT3 N0 M0 in the 8th TNM staging system TNM UICC/AJCC
  7. Availability of thoracic Computed-Tomography (CT) scan with IV contrast (in the absence of contra-indications) performed before treatment
  8. Availability of a thoracic Computed-Tomography (CT) scan with IV contrast showing absence of residual disease after surgical resection of the tumor
  9. Pulmonary function tests after surgery with FEV1 > 1L or ≥ 35% of the theoretical value and DLCO ≥ 40%
  10. Signature of informed consent form
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Exclusion Criteria
    1. Age > 75 years old 2. Histology of thymic carcinoma 3. Delivery of post-operative chemotherapy, concurrent chemotherapy to radiotherapy 4. Presence of microscopic or macroscopic residual tumor after surgery or metastases (R1 or R2 resection) 5. Uncontrolled, clinically significant pleural or pericardial effusion 6. Patients with prior radiation therapy to the thorax. Patients treated with conformal radiotherapy for prior breast or head and neck neoplasms should be discussed with PI 7. Evidence of severe or uncontrolled systemic disease as judged by the investigator 8. Recent (< 6 months) severe cardiac disease (uncontrolled arrhythmia, congestive heart failure, infarction, pace-maker) or pulmonary disease. Controlled and non clinically symptomatic arrhythmia is allowed.
  1. Current or past history of neoplasm diagnosed within the last 3 years, except: basal cell carcinoma of the skin, in situ carcinoma of the cervix, and bladder in situ. A patient diagnosed for another neoplasm 3 years ago or more, treated and considered as cured may be included in the study if all the other criteria are respected 10. Pregnancy or breast feeding or inadequate contraceptive measures for women of childbearing potential during PORT 11. Patients who, for family, social, geographic or psychological reasons, cannot be adequately followed up and/or are incapable of undergoing regular controls, 12. Patients deprived of freedom or under guardianship
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Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Post-operative radiotherapyRadiotherapyTumour resection followed by radiotherapy.
Surveillance after tumour resectionSurveillance after resectionTumour resection
Primary Outcome Measures
NameTimeMethod
Recurrence-Free survival (RFS)3 years

to compare the Recurrence-Free survival (RFS) between arms. RFS is defined as time from randomisation to the first recurrence (either local-regional or distant) or death of any cause.

Secondary Outcome Measures
NameTimeMethod
Local-regional (pleural or pericardial) recurrence3 years

Local-regional (pleural or pericardial) recurrence; location of recurrence /removed

Trial Locations

Locations (18)

CLCC Henri Becquerel

🇫🇷

Rouen, France

Gustave Roussy

🇫🇷

Villejuif, France

AP-HM Hôpital Nord

🇫🇷

Marseille, France

CHU Lyon

🇫🇷

Lyon, France

CHU Caen

🇫🇷

Caen, France

CLCC François BACLESSE

🇫🇷

Caen, France

Institut de Cancérologie de Lorraine Nancy

🇫🇷

Vandœuvre-lès-Nancy, France

Centre Oscar Lambret

🇫🇷

Lille, France

CHU Rennes Hôpital Sud

🇫🇷

Rennes, France

CLCC Georges François Leclerc

🇫🇷

Dijon, France

CHU Rouen

🇫🇷

Rouen, France

Institut de Cancérologie de l'Ouest

🇫🇷

Saint-Herblain, France

CHRU Tours

🇫🇷

Tours, France

Institut Claudius Regaud

🇫🇷

Toulouse, France

Institut du Cancer de Montpellier

🇫🇷

Montpellier, France

Hôpital Bichat AP-HP

🇫🇷

Paris, France

CHU Strasbourg

🇫🇷

Strasbourg, France

Institut Curie

🇫🇷

Paris, France

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