Assessing Causality of the Association Between Exercise and Neurocognitive Gains
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 93
- 试验地点
- 1
- 主要终点
- N-Back task change
研究概览
简要总结
Brief Summary: The aim of this project is to examine:
- The effects of a community based square stepping exercise programme on cognitive and physical functions in older adults.
- The effects of a community based square stepping exercise programme on neuroplasticity in older adults.
- The effects of a community based square stepping exercise programme on structural and functional brain changes in older adults.
- The relationship between exercise-induced changes in neuroplasticity, structural and functional brain activations, and cognitive and physical gains in older adults.
详细描述
It is well known regular exercise produces both physical and cognitive benefits. Emerging evidence suggests that physical movements or exercise that have concurrent cognitive demands may have more profound effects on cognitive and brain health outcomes. One training program that incorporates these components is the square stepping exercise (SSE). First demonstrated in Japan, this community-based paradigm has already shown to reduce falls risk and presents as a convenient exercise modality for older adults, that can be conducted in a group setting or even the home. The current project aims to examine the efficacy of this SSE community programme in a Singapore context on cognitive and physical health in older adults. This study also aims to quantify the neural correlates underpinning any observed improvements in cognitive and physical function. Specifically, this project will measure indices of neuroplasticity via structural and functional magnetic resonance imaging, transcranial magnetic stimulation, and electroencephalography.
Sample size estimation: n=80 for behavioural primary outcome measures and n=40 subset of larger sample for neuroimaging and neuroplasticity secondary outcome measures [anticipated].
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Older adults aged 55-80
- •Sedentary, defined as exercise less than 3 times per week for 30 minutes
排除标准
- •Square stepping exercise:
- •Medical conditions preventing them from movement and/or exercise
- •Psychiatric conditions
- •Cognitive impairment of dementia
- •Upper and/or lower limb injuries in the past 6 months
- •History of falls in the past 6 months
- •Current smokers
- •Neuroimaging (all the above in addition to the following)
- •Patients who have conductive, ferromagnetic, or magnet-sensitive metals implanted in head (e.g., aneurysm clip, stent).
- •Implanted medical device: e.g., cardiac implants, cochlear implant, aneurysm clips, cardiac pacemaker etc.
- •Non-removable metal braces or retainer (dental fillings ok).
- •Permanent tattoos on head.
- •Deep brain stimulators.
- •Previous brain surgery or injury.
- •Patient with epilepsy or any other seizure history, or immediate family history of epilepsy.
- •Clinical EEG that was abnormal or where seizure activity had not been ruled out.
- •Patients with history of head injury with loss of consciousness are to be investigated about the history if/before being recruited.
- •Diagnosis or possibility of neurological disorder (including stroke).
- •Psychiatric condition.
- •Major or unstable medical condition/surgery.
- •Current or suspected pregnancy or lactation.
- •Illicit drug use in the last 7 days.
- •Alcohol use in the last 12 hours or more than 3 standard drinks in last 24 hours.
- •Recent insomnia or severe sleep deprivation.
- •Participation in another study involving brain stimulation (e.g., TMS, TDCS) in the past 7 days.
研究组 & 干预措施
Exercise-Cognition
Square Stepping Exercise
干预措施: exercise (Other)
No exercise
Passive control group
结局指标
主要结局
N-Back task change
时间窗: Baseline (week 0), mid-intervention (week 7 after session 12), post-intervention (week 13 after session 24)
Number of correct responses (hits)
Static balance (single leg) change
时间窗: Baseline (week 0), post-intervention (week 13 after session 24)
Duration required to perform single leg stance on left and right legs
Modified Card Sorting task change
时间窗: Baseline (week 0), mid-intervention (week 7 after session 12), post-intervention (week 13 after session 24)
Total number of perseverative errors
Motor learning change
时间窗: Baseline (week 0), post-intervention (week 13 after session 24)
Probabilistic Serial Reaction Time Task: learning index, computed using reaction time
Go-No-Go task change
时间窗: Baseline (week 0), mid-intervention (week 7 after session 12), post-intervention (week 13 after session 24)
Error rate: Number of "Go" responses on "No-Go" trials.
Stroop task colour words and colour blocks
时间窗: Baseline (week 0), mid-intervention (week 7 after session 12), post-intervention (week 13 after session 24)
Average response time (reaction time) for the correct colour word incongruent trials.
Trail Making Test ((TMT) change
时间窗: Baseline (week 0), mid-intervention (week 7 after session 12), post-intervention (week 13 after session 24)
B:A: Divide the time taken for TMT B by TMT A
Digit Span task change
时间窗: Baseline (week 0), mid-intervention (week 7 after session 12), post-intervention (week 13 after session 24)
Maximum accurate span length for Digit Span Forward Maximum accurate span length for Digit Span Reverse
Temporal gait parameters change
时间窗: Baseline (week 0), post-intervention (week 13 after session 24)
11-meter gait test to examine gait speed
次要结局
- Brain plasticity changes(Baseline (week 0), post-intervention (week 13 after session 24))
- Change in white matter integrity(Baseline (week 0), post-intervention (week 13 after session 24))
- Change in grey matter volume(Baseline (week 0), post-intervention (week 13 after session 24))
- Change in structural topography(Baseline (week 0), post-intervention (week 13 after session 24))
- Change in functional connectivity(Baseline (week 0), post-intervention (week 13 after session 24))
- Change in cortical thickness(Baseline (week 0), post-intervention (week 13 after session 24))
- Change in white matter connectivity(Baseline (week 0), post-intervention (week 13 after session 24))
研究者
SH Annabel Chen, PhD
Professor of Psychology, School of Social Sciences
Nanyang Technological University