CorKid (COVID19/ SARS-CoV-2 seroconversion in kids)

• Conditions: U07.1; COVID-19, virus identified

• Registration Number: DRKS00022434
• Lead Sponsor: niversitätskinderklinik im St.-Josef Hospital Klinikum der Ruhr-Universität-Bochum

Brief Summary

IntroductionSocio-economic and ethnic background have been discussed as possible risk factors for SARS-CoV-2 infections in children. Improved knowledge could lead to tailored prevention strategies and help improve infection control.AimWe aimed to identify risk factors for SARS-CoV-2 infections in children in the first and second wave of the pandemic.MethodsWe performed an observational population-based cohort study in children (6 months-18 years) scheduled for legally required preventive examination and their parents in a metropolitan region in Germany. Primary endpoint was the SARS-CoV-2 seroconversion rate during the study period. Risk factors assessed included age, pre-existing medical conditions, socio-economic factors and ethnicity.ResultsWe included 2,124 children and their parents. Seroconversion rates among children in all age groups increased 3-4-fold from June 2020 to February 2021. Only 24 of 58 (41%) seropositive children reported symptoms. In 51% of infected children, at least one parent was also SARS-CoV-2-positive. Low level of parental education (OR = 3.13; 95% CI: 0.72-13.69) non-significantly increased the risk of infection. Of the total cohort, 38.5% had a migration background, 9% of Turkish and 5% of Middle Eastern origin, and had the highest risk for SARS-CoV-2 infections (OR = 6.24; 95% CI: 1.38-28.12 and OR = 6.44 (95% CI: 1.14-36.45) after adjustment for other risk factors.ConclusionIn the second half of 2020, seroprevalence for SARS-CoV-2 in children increased especially in families with lower-socioeconomic status. Culture-sensitive approaches are essential to limit transmission and could serve as a blueprint for vaccination strategies

Detailed Description

Not available

Study Timeline

• Study Start: 2020-08-07
• Study Completion: 2022-02-28
• Results First Posted: 2022-09-15
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 2149

Inclusion Criteria

6 months– 18 years
- Patients who present in the practice for routine medical screening (U-Untersuchungen)
- signed consent
- Mothers or other family members (fathers, siblings) of the subjects primarily included (of all ages from 6 months)

Exclusion Criteria

no consent to the study

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
In children and adolescents, seroconversion rate for SARS-CoV-2 will be detectable in 10-20% within the observation period of 6 months<br><br>

Secondary Outcome Measures

Name	Time	Method
In children and adolescents, there are risk factors such as certain polymorphisms in the ACE2 receptor or pulmonary pre-existing conditions for more severe courses of a COVID-19 infections.