Resistance Training Effects on Gut Microbiome and Cardiometabolic Outcomes

Not Applicable

Completed

• Conditions: Exercise Intervention
• Interventions: Other: Conventional physical activity guidelines; Behavioral: Resistance training

• Registration Number: NCT04906525
• Lead Sponsor: University of Missouri-Columbia

Brief Summary

The overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.

Detailed Description

The overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.

Study Timeline

• Study First Submitted: 2021-05-05
• Study Start: 2021-05-19
• Study First Submitted QC: 2021-05-24
• Study First Posted: 2021-05-28
• Primary Completion: 2022-09-30
• Study Completion: 2022-09-30
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-09
• Last Update Posted: 2023-03-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Age 18-35 years
• BMI: 25-45 kg/m2
• Sedentary lifestyle
• Consistent diet patterns
• Weight-stable (<4 kg change over the last 3 mo)
• Willingness to adhere to resistance training protocol and not change diet
• Non-smoker >1 year or more

Exclusion Criteria

• Disabilities preventing adherence to resistance training protocol
• Recent start of medications that affect metabolism or appetite
• Antibiotics
• Diabetes
• Drug therapy for coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia
• Uncontrolled hypertension and blood pressure ≥ 180/110
• Gastrointestinal disease and/or bariatric surgery
• Smoking
• Illicit drug use
• Pregnant or lactating individuals

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Conventional physical activity guidelines	Conventional physical activity guidelines	Participants are given recommendations on physical activity guidelines
Resistance training	Resistance training	Participants will undergo 6 weeks of supervised resistance training

Primary Outcome Measures

Name	Time	Method
Change in stool microbiome composition	Change over 6 weeks	16s rRNA sequencing
Change in stool microbiome diversity	Change over 6 weeks	16s rRNA sequencing

Secondary Outcome Measures

Name	Time	Method
Fat mass	Change over 6 weeks	body composition
Sleep Quality	change over 6 weeks	Measured using actigraphs
24hr appetite ratings	Once at baseline and at the end of 6 week intervention	Subjective rating using visual analog scales
Change in Body mass	change over 6 weeks	Measured in kg
Hip circumference	change over 6 weeks	anthropometrics
Physical activity	change over 6 weeks	kcalories burned during free living activity measured by accelerometer
Change in blood pressure	change over 6 weeks	diastolic and systolic blood pressure
Fat free mass	Change over 6 weeks	body composition
Change in glucose regulation	change over 6 weeks	2 hour glucose clearance
Sleep Duration	change over 6 weeks	Measured using actigraphs
Change in fasting glucose	change over 6 weeks	Fasting Glucose
Waist circumference	change over 6 weeks	anthropometrics
Short chain fatty acids	Change over 6 weeks	Acetate, propionate, and butyrate

Trial Locations

Locations (1)

University of Missouri; 🇺🇸 Columbia, Missouri, United States